蒲公英提取物抗铝致神经毒性及神经保护作用

Advances in biomarker sciences and technology Pub Date : 2026-11-01 Epub Date: 2025-12-29 DOI:10.1016/j.abst.2025.12.010

Idorenyin U. Umoren , Nnanake-Abasi O. Offiong , Niibari W. Vite

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引用次数: 0

摘要

研究了蒲公英叶提取物及其提取物对氯化铝致大鼠神经毒性的抗氧化和神经保护作用。将66只雌性Wistar大鼠分为11组，分别给予对照、氯化铝、多奈哌齐或不同剂量/部位的植物提取物21 d。氯化铝显著降低了抗氧化酶（SOD、CAT、GPx）活性，增加了脂质过氧化（MDA）。乙醇提取物、二氯甲烷、乙酸乙酯和正丁醇组分共处理恢复了抗氧化防御能力，降低了MDA水平，而正己烷和水溶液组分作用不大。这些发现表明，蒲公英含有抗氧化应激和神经损伤的生物活性化合物，支持其作为天然神经保护剂的潜力。

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Antioxidant and neuroprotective effects of Launaea taraxacifolia extract against aluminum-induced neurotoxicity

This study evaluated the antioxidant and neuroprotective effects of ethanol leaf extract and fractions of Launaea taraxacifolia against aluminum chloride-induced neurotoxicity in rats. Sixty-six female Wistar rats were divided into eleven groups, receiving either control treatment, aluminum chloride, donepezil, or different doses/fractions of the plant extract for 21 days. Aluminum chloride significantly reduced antioxidant enzyme activities (SOD, CAT, GPx) and increased lipid peroxidation (MDA). Co-treatment with the ethanol extract, dichloromethane, ethylacetate, and n-butanol fractions restored antioxidant defenses and reduced MDA levels, whereas the n-hexane and aqueous fractions showed little effect. These findings indicate that Launaea taraxacifolia contains bioactive compounds with protective effects against oxidative stress and neuronal injury, supporting its potential as a natural neuroprotective agent.

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来源期刊

Advances in biomarker sciences and technology Biotechnology, Clinical Biochemistry, Molecular Medicine, Public Health and Health Policy

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审稿时长

20 weeks