左伏隔核体积与髋关节骨关节炎患者睡眠质量差有关

Q2 Medicine

Neurobiology of Pain Pub Date : 2025-07-01 Epub Date: 2025-11-13 DOI:10.1016/j.ynpai.2025.100203

Natalia Egorova-Brumley , Luiza Bonfim Pacheco , Gabby Knox , Leila Nategh , Fiona Dobson , Michelle Hall

{"title":"左伏隔核体积与髋关节骨关节炎患者睡眠质量差有关","authors":"Natalia Egorova-Brumley , Luiza Bonfim Pacheco , Gabby Knox , Leila Nategh , Fiona Dobson , Michelle Hall","doi":"10.1016/j.ynpai.2025.100203","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>Reduction in the volume of the nucleus accumbens (NAc) has emerged as a promising signature of chronic pain transition, including in osteoarthritis (OA). Yet, less is known about the factors that could influence these changes in the mesolimbic system. Given that poor sleep is common in OA, and recent studies of sleep disturbance on pain perception in animals and healthy populations have specifically implicated the NAc, we hypothesised that the left NAc volume in hip OA would be associated with sleep quality and quantity. Furthermore, we explored how sex interacts with this relationship.</div></div><div><h3>Methods</h3><div>Cross-sectional study in participants with hip OA (n = 34; aged 60+/-12 years, 67 % females) who reported moderate pain were recruited.</div></div><div><h3>Results</h3><div>A one-sample <em>t</em>-test showed that the left NAc volumes were significantly lower than normative values (t = -2.7368, df = 33, p-value = 0.009). In a model (F(4, 29) = 6.642, p < 0.001, R2 = 0.4781) including the total intracranial volume (TIV), sex and age, the left NAc volume was significantly predicted by sleep quality (t = -3.416, p = 0.002) assessed with Pittsburgh Sleep Quality Index (PSQI). Sleep efficiency (t = 2.362, p = 0.025) but not hours spent in bed (p > 0.05) was also a significant predictor. With models exploring sleep*sex interactions, only sleep efficiency demonstrated an interaction, suggesting that the left NAc volume is lower in females with worse sleep efficiency (t = -2.086, p = 0.046, albeit not significant when corrected for multiple comparisons, pFDR = 0.138.)</div></div><div><h3>Conclusions</h3><div>Our results suggest that the reduction of the NAc volumes as a candidate biomarker of pain might be influenced by sleep. This exploratory finding in a chronic hip OA population is consistent with the results previously only reported in animal and experimental pain/sleep studies in healthy participants.</div></div><div><h3>Significance</h3><div>The left NAc as a candidate biomarker of chronic pain is sensitive to the effects of sleep quality, especially in females with OA.</div></div>","PeriodicalId":52177,"journal":{"name":"Neurobiology of Pain","volume":"18 ","pages":"Article 100203"},"PeriodicalIF":0.0000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Left nucleus accumbens volume is associated with poor sleep in hip osteoarthritis\",\"authors\":\"Natalia Egorova-Brumley , Luiza Bonfim Pacheco , Gabby Knox , Leila Nategh , Fiona Dobson , Michelle Hall\",\"doi\":\"10.1016/j.ynpai.2025.100203\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><div>Reduction in the volume of the nucleus accumbens (NAc) has emerged as a promising signature of chronic pain transition, including in osteoarthritis (OA). Yet, less is known about the factors that could influence these changes in the mesolimbic system. Given that poor sleep is common in OA, and recent studies of sleep disturbance on pain perception in animals and healthy populations have specifically implicated the NAc, we hypothesised that the left NAc volume in hip OA would be associated with sleep quality and quantity. Furthermore, we explored how sex interacts with this relationship.</div></div><div><h3>Methods</h3><div>Cross-sectional study in participants with hip OA (n = 34; aged 60+/-12 years, 67 % females) who reported moderate pain were recruited.</div></div><div><h3>Results</h3><div>A one-sample <em>t</em>-test showed that the left NAc volumes were significantly lower than normative values (t = -2.7368, df = 33, p-value = 0.009). In a model (F(4, 29) = 6.642, p < 0.001, R2 = 0.4781) including the total intracranial volume (TIV), sex and age, the left NAc volume was significantly predicted by sleep quality (t = -3.416, p = 0.002) assessed with Pittsburgh Sleep Quality Index (PSQI). Sleep efficiency (t = 2.362, p = 0.025) but not hours spent in bed (p > 0.05) was also a significant predictor. With models exploring sleep*sex interactions, only sleep efficiency demonstrated an interaction, suggesting that the left NAc volume is lower in females with worse sleep efficiency (t = -2.086, p = 0.046, albeit not significant when corrected for multiple comparisons, pFDR = 0.138.)</div></div><div><h3>Conclusions</h3><div>Our results suggest that the reduction of the NAc volumes as a candidate biomarker of pain might be influenced by sleep. This exploratory finding in a chronic hip OA population is consistent with the results previously only reported in animal and experimental pain/sleep studies in healthy participants.</div></div><div><h3>Significance</h3><div>The left NAc as a candidate biomarker of chronic pain is sensitive to the effects of sleep quality, especially in females with OA.</div></div>\",\"PeriodicalId\":52177,\"journal\":{\"name\":\"Neurobiology of Pain\",\"volume\":\"18 \",\"pages\":\"Article 100203\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neurobiology of Pain\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2452073X2500025X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/11/13 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurobiology of Pain","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2452073X2500025X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/11/13 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

摘要

伏隔核（NAc）体积的减少已成为慢性疼痛过渡的一个有希望的标志，包括骨关节炎（OA）。然而，人们对影响中边缘系统这些变化的因素知之甚少。鉴于睡眠质量差在OA患者中很常见，并且最近在动物和健康人群中关于睡眠障碍对疼痛感知的研究特别涉及了NAc，我们假设髋OA患者左侧NAc体积与睡眠质量和睡眠量有关。此外，我们还探讨了性如何与这种关系相互作用。方法对报告中度疼痛的髋关节OA患者（34例，年龄60+/-12岁，67%为女性）进行横断面研究。结果单样本t检验结果显示，左NAc体积显著低于正常值（t = -2.7368, df = 33， p值= 0.009）。在包含颅内总容积（TIV）、性别和年龄的模型（F(4,29) = 6.642, p < 0.001, R2 = 0.4781）中，以匹兹堡睡眠质量指数（PSQI）评估的睡眠质量（t = -3.416, p = 0.002）显著预测左NAc容积。睡眠效率（t = 2.362, p = 0.025），而非卧床时间（p > 0.05）也是显著的预测因子。在探索睡眠与性别相互作用的模型中，只有睡眠效率显示出了相互作用，这表明睡眠效率较差的女性左NAc体积更低（t = -2.086, p = 0.046，尽管在进行多重比较校正后并不显著，pFDR = 0.138）。结论NAc体积的减少作为疼痛的候选生物标志物可能受到睡眠的影响。这一在慢性髋关节炎人群中的探索性发现与之前仅在健康参与者的动物和实验性疼痛/睡眠研究中报道的结果一致。左侧NAc作为慢性疼痛的候选生物标志物对睡眠质量的影响很敏感，尤其是在OA女性患者中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Left nucleus accumbens volume is associated with poor sleep in hip osteoarthritis

Objective

Reduction in the volume of the nucleus accumbens (NAc) has emerged as a promising signature of chronic pain transition, including in osteoarthritis (OA). Yet, less is known about the factors that could influence these changes in the mesolimbic system. Given that poor sleep is common in OA, and recent studies of sleep disturbance on pain perception in animals and healthy populations have specifically implicated the NAc, we hypothesised that the left NAc volume in hip OA would be associated with sleep quality and quantity. Furthermore, we explored how sex interacts with this relationship.

Methods

Cross-sectional study in participants with hip OA (n = 34; aged 60+/-12 years, 67 % females) who reported moderate pain were recruited.

Results

A one-sample t-test showed that the left NAc volumes were significantly lower than normative values (t = -2.7368, df = 33, p-value = 0.009). In a model (F(4, 29) = 6.642, p < 0.001, R2 = 0.4781) including the total intracranial volume (TIV), sex and age, the left NAc volume was significantly predicted by sleep quality (t = -3.416, p = 0.002) assessed with Pittsburgh Sleep Quality Index (PSQI). Sleep efficiency (t = 2.362, p = 0.025) but not hours spent in bed (p > 0.05) was also a significant predictor. With models exploring sleep*sex interactions, only sleep efficiency demonstrated an interaction, suggesting that the left NAc volume is lower in females with worse sleep efficiency (t = -2.086, p = 0.046, albeit not significant when corrected for multiple comparisons, pFDR = 0.138.)

Conclusions

Our results suggest that the reduction of the NAc volumes as a candidate biomarker of pain might be influenced by sleep. This exploratory finding in a chronic hip OA population is consistent with the results previously only reported in animal and experimental pain/sleep studies in healthy participants.