一种抗白血病物质的分离鉴定。

Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology Pub Date : 1987-10-01

L N Anisova, Iu E Bartoshevich, O A Efremenkova, O L Krasil'nikova, M K Kudinova

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引用次数: 0

摘要

研究了在琼脂培养基上培养辐射角担子菌及其浸没发酵的条件。用乙酸乙酯萃取，硅胶柱纯化，从发酵液滤液中分离出一种抗生素。该抗生素对血母细胞病有明显的体内抑制作用。光谱分析(紫外、红外、核磁共振和质谱)表明，该抗生素与一种毒素展霉素相同。

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[Isolation and identification of an antileukemia substance from Coprinus radiatus].

Conditions for cultivation of basidiomycete Coprinus radiatus on agar media and its submersion fermentation were developed. An antibiotic was isolated from the fermentation broth filtrate by extraction with ethyl acetate followed by purification on a column with silica gel. The antibiotic had a pronounced in vivo effect on hemoblastosis La. Spectral analysis of the antibiotic (UV, IR, NMR and mass spectra) showed that it was identical to patulin (a toxin).

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Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology

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