不同强度进行性体育锻炼对幼鼠生长板闭合的影响。

IF 1.4 4区医学 Q4 HEALTH CARE SCIENCES & SERVICES

Journal of Manipulative and Physiological Therapeutics Pub Date : 2025-07-01 Epub Date: 2025-11-12 DOI:10.1016/j.jmpt.2025.10.014

Márcia R. de Andrade MSc , Alessandro de Oliveira PhD , Luan A. Pereira MSc , Ismael A.L. Santos BSc , Maria Eduarda P. Campos BSc , Luna S.C. Vaz BSc , Laila C.M. Damázio PhD

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引用次数: 0

摘要

目的：研究幼龄大鼠高、中强度体育锻炼后生长板的形态变化。方法：采用Wistar大鼠24只，随机分为3组：未训练对照组（RC）、高强度体育锻炼组（R1）和中强度体育锻炼组（R2）。采用调整体重的阶梯训练方案（每周5次，持续4周）。在苏木精-伊红和Gomori三色染色后，在纵向切片上对右胫骨GP进行组织形态学分析，并进行细胞计数和GP厚度测量。采用单因素方差分析和Tukey事后检验（α < 0.05）进行均值分析。结果：与对照组（407.6 μm和1329.7）和中等强度组（312.4 μm和1328.5）相比，高强度运动组（355.5 μm和1157.3）的GP厚度和软骨细胞计数较低。结论：与对照组相比，高强度和中等强度的训练促进了年轻大鼠GP的降低。因此，阶梯训练方案可能预期幼鼠GP关闭，从而损害这些动物的胫骨长度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Effect of Different Intensities of Progressive Physical Exercise on Growth Plate Closure in Young Rats

Objective

The aim of this study was to investigate the morphology of growth plates (GP) in young rats submitted to high and medium-intensity physical exercise.

Methods

The sample consisted of 24 Wistar rats divided into 3 groups: untrained controls (RC), high-intensity physical exercise (R1), and medium-intensity physical exercise (R2). A weight-adjusted ladder training protocol was adopted (five times a week for 4 weeks). Histomorphometric analysis of the GP of the right tibia was performed in a longitudinal section after staining with hematoxylin-eosin and Gomori’s trichrome, in addition to cell counts and GP thickness measurements. One-way ANOVA and Tukey’s post-test (α < 0.05) were used to analyze the means.

Results

The GP presented inferior thickness and chondrocyte counts in the group that underwent high-intensity physical training (355.5 μm and 1157.3) compared to the control (407.6 μm and 1329.7) and medium-intensity groups (312.4 μm and 1328.5).

Conclusion

High and medium-intensity training promoted a reduction in the GP of young rats compared to the control group. Therefore, ladder training protocols may anticipate GP closure in young rats, thus impairing tibial length in these animals.

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来源期刊

Journal of Manipulative and Physiological Therapeutics 医学-康复医学

CiteScore

3.00

自引率

7.70%

发文量

审稿时长

29 weeks

期刊介绍： The Journal of Manipulative and Physiological Therapeutics (JMPT) is an international and interdisciplinary journal dedicated to the advancement of conservative health care principles and practices. The JMPT is the premier biomedical publication in the chiropractic profession and publishes peer reviewed, research articles and the Journal''s editorial board includes leading researchers from around the world. The Journal publishes original primary research and review articles of the highest quality in relevant topic areas. The JMPT addresses practitioners and researchers needs by adding to their clinical and basic science knowledge and by informing them about relevant issues that influence health care practices.