{"title":"[基因组学的六层结构:整合研究、测试和治疗的强大概念框架]。","authors":"Naoyuki Kamatani","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Genomic data are now available from various fields of medicine and biology, and I proposed a conceptual framework \"Six-layer structure\" to integrate various areas of genomics. The proposed layers are \"life\" as the uppermost layer, followed by \"species\",\"population\",\"family\",\"individual\",and finally \"cell\" as the bottommost layer. In each pair of adjacent layers, each member of the upper layer comprises a set of members of the lower layer. In each layer, we can define consistent partial orders of members based on genomic data in the forms of phylogenic and pedigree trees. Based on this framework, we can give integrated explanations for various researches, tests and drug therapies concerning genomic data, and we can use this framework for new discoveries as well as new test and drug developments.</p>","PeriodicalId":502100,"journal":{"name":"Clinical calcium","volume":"26 4","pages":"579-85"},"PeriodicalIF":0.0000,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[ix-layer structure for genomics:A powerful conceptual framework that integrates research, test and treatment].\",\"authors\":\"Naoyuki Kamatani\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Genomic data are now available from various fields of medicine and biology, and I proposed a conceptual framework \\\"Six-layer structure\\\" to integrate various areas of genomics. The proposed layers are \\\"life\\\" as the uppermost layer, followed by \\\"species\\\",\\\"population\\\",\\\"family\\\",\\\"individual\\\",and finally \\\"cell\\\" as the bottommost layer. In each pair of adjacent layers, each member of the upper layer comprises a set of members of the lower layer. In each layer, we can define consistent partial orders of members based on genomic data in the forms of phylogenic and pedigree trees. Based on this framework, we can give integrated explanations for various researches, tests and drug therapies concerning genomic data, and we can use this framework for new discoveries as well as new test and drug developments.</p>\",\"PeriodicalId\":502100,\"journal\":{\"name\":\"Clinical calcium\",\"volume\":\"26 4\",\"pages\":\"579-85\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2016-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical calcium\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical calcium","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
[ix-layer structure for genomics:A powerful conceptual framework that integrates research, test and treatment].
Genomic data are now available from various fields of medicine and biology, and I proposed a conceptual framework "Six-layer structure" to integrate various areas of genomics. The proposed layers are "life" as the uppermost layer, followed by "species","population","family","individual",and finally "cell" as the bottommost layer. In each pair of adjacent layers, each member of the upper layer comprises a set of members of the lower layer. In each layer, we can define consistent partial orders of members based on genomic data in the forms of phylogenic and pedigree trees. Based on this framework, we can give integrated explanations for various researches, tests and drug therapies concerning genomic data, and we can use this framework for new discoveries as well as new test and drug developments.