[类风湿关节炎全基因组关联研究]。

Clinical calcium Pub Date : 2016-04-01

Yuta Kochi

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引用次数: 0

摘要

类风湿性关节炎（RA）是一种多因素疾病，涉及遗传和环境因素。全基因组关联研究已经确定了100多个与类风湿关节炎相关的位点。这些基因座大部分是表达数量性状基因座（eqtl），其中遗传变异调节转录水平。在这里，我通过描述RA相关基因如HLA-DRB1、PADI4和CCR6来回顾RA的遗传背景。

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[Genome-wide association study for rheumatoid arthritis].

Rheumatoid arthritis(RA)is a multifactorial disease, where both genetic and environmental factors are involved. Genome-wide association studies have been identified more than 100 loci associated with RA. Majority of these loci are expression quantitative trait loci(eQTLs), in which genetic variants regulate the level of transcription. Here, I review the genetic background of RA, by describing the RA-associated genes such as HLA-DRB1, PADI4, and CCR6.

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Clinical calcium

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