非典型股骨骨折和双膦酸盐。

Clinical calcium Pub Date : 2017-01-01

Noriaki Yamamoto

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引用次数: 0

摘要

双膦酸盐治疗已广泛应用于骨质疏松症患者，非典型股骨骨折（AFF）在这些患者中被报道为双膦酸盐治疗的不寻常效果。AFF的发病机制被认为是双膦酸盐过度抑制骨转换。然而，最近的研究表明，其他因素与AFF的发生有关。为了解决骨质疏松症的临床不良事件，还需要进一步的研究来阐明AFF的作用机制。

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[Atypical femoral fracture and Bisphosphonate.]

Bisphosphonate therapy had been spread widely in osteoporosis patients, atypical femoral fractures(AFF)were reported in these patients as the unusual effects of bisphosphonate treatment. The pathogenesis of AFF was considered to be an over suppression of bone turnover by bisphosphonate. However recent studies indicated other factors related to AFF initiation. Further studies are required to clarify the mechanism of AFF in order to resolve this adverse events in osteoporosis clinic.

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Clinical calcium

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