核激素受体nhr-76诱导秀丽隐杆线虫年龄依赖性趋化性下降。

IF 7.1 1区医学 Q1 CELL BIOLOGY

Aging Cell Pub Date : 2025-10-23 DOI:10.1111/acel.70277

Rikuou Yokosawa, Kentaro Noma

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引用次数: 0

摘要

生殖后动物寻找食物行为的减少对种群有益，尽管对个体有害，但可能是由基因组决定的。我们研究了秀丽隐杆线虫对细菌食物分泌的气味趋化行为的年龄依赖性下降的遗传程序。通过一种新的正向遗传筛选，我们发现了编码核激素受体的基因nhr-76，其突变改善了年龄依赖性趋化性下降。我们发现NHR-76在衰老过程中以配体结合结构域依赖的方式下调气味受体的表达。由于NHR-76的表达和定位随着年龄的增长而保持不变，其活性可能通过配体结合结构域进行调节，导致年龄依赖性趋化性下降。我们的研究结果表明，生殖后行为的下降可能是由基因决定的。

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A Nuclear Hormone Receptor nhr-76 Induces Age-Dependent Chemotaxis Decline in C. elegans.

A decline in food-searching behavior of post-reproductive animals can benefit the population and possibly be programmed by the genome despite its detrimental effect on an individual. We investigated the genetic program of age-dependent decline in chemotaxis behavior toward an odorant secreted from bacterial food in C. elegans. Through a novel forward genetic screen, we identified the gene encoding a nuclear hormone receptor, nhr-76, whose mutants ameliorate the age-dependent chemotaxis decline. We found that NHR-76 downregulates odorant receptor expression during aging in a ligand-binding-domain-dependent manner. Since NHR-76 expression and localization remain unchanged with age, its activity may be modulated through the ligand-binding domain, leading to age-dependent chemotaxis decline. Our findings imply that post-reproductive behavioral decline can be genetically programmed.

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来源期刊

Aging Cell Biochemistry, Genetics and Molecular Biology-Cell Biology

自引率

2.60%

发文量

212

期刊介绍： Aging Cell is an Open Access journal that focuses on the core aspects of the biology of aging, encompassing the entire spectrum of geroscience. The journal's content is dedicated to publishing research that uncovers the mechanisms behind the aging process and explores the connections between aging and various age-related diseases. This journal aims to provide a comprehensive understanding of the biological underpinnings of aging and its implications for human health. The journal is widely recognized and its content is abstracted and indexed by numerous databases and services, which facilitates its accessibility and impact in the scientific community. These include: Academic Search (EBSCO Publishing) Academic Search Alumni Edition (EBSCO Publishing) Academic Search Premier (EBSCO Publishing) Biological Science Database (ProQuest) CAS: Chemical Abstracts Service (ACS) Embase (Elsevier) InfoTrac (GALE Cengage) Ingenta Select ISI Alerting Services Journal Citation Reports/Science Edition (Clarivate Analytics) MEDLINE/PubMed (NLM) Natural Science Collection (ProQuest) PubMed Dietary Supplement Subset (NLM) Science Citation Index Expanded (Clarivate Analytics) SciTech Premium Collection (ProQuest) Web of Science (Clarivate Analytics) Being indexed in these databases ensures that the research published in Aging Cell is discoverable by researchers, clinicians, and other professionals interested in the field of aging and its associated health issues. This broad coverage helps to disseminate the journal's findings and contributes to the advancement of knowledge in geroscience.