病理证实与未证实的子宫内膜异位症与焦虑和抑郁之间的关系

IF 3.3 2区医学 Q1 OBSTETRICS & GYNECOLOGY

Journal of minimally invasive gynecology Pub Date : 2025-10-22 DOI:10.1016/j.jmig.2025.09.033

K Lawrenson , N Ngo , S Taing , M Liang , A Manlinguez , R Meyer

{"title":"病理证实与未证实的子宫内膜异位症与焦虑和抑郁之间的关系","authors":"K Lawrenson , N Ngo , S Taing , M Liang , A Manlinguez , R Meyer","doi":"10.1016/j.jmig.2025.09.033","DOIUrl":null,"url":null,"abstract":"<div><h3>Study Objective</h3><div>Among patients with endometriosis, disease symptoms associate poorly with lesion burden, and severe symptoms of endometriosis can occur in patients in whom lesions cannot be detected by pathologic examination. Anxiety and depression are prevalent in patients with confirmed endometriosis. This study aimed to examine these comorbid traits in patients with endometriosis-like symptoms in the absence of a confirmed diagnosis.</div></div><div><h3>Design</h3><div>A prospective study. We collected data from patients who underwent surgery for endometriosis and controls who underwent surgery for other indications between 10/2019 and 3/2024, as part of The Biologic and Epidemiologic Markers of Endometriosis (BEME) clinic-based study.</div></div><div><h3>Setting</h3><div>Quaternary level hospital.</div></div><div><h3>Patients or Participants</h3><div>We compared patients with pathology confirmed endometriosis to patients with suspected endometriosis and negative pathology (SENP) and controls.</div></div><div><h3>Interventions</h3><div>Multivariable regressions analysis to evaluate the association between pathology confirmed endometriosis and medically treated anxiety and/or depression.</div></div><div><h3>Measurements and Primary Results</h3><div>454 women were included in the study, of which 308 (67.8%) had pathology confirmed endometriosis, 45 (9.9%) had SENP, and 101 (22.2%) were controls without endometriosis. The proportion of depression among patients with pathology confirmed endometriosis, SENP and controls 42.4%, 60.0% and 40.6%, respectively. The proportion of anxiety among the groups was 52.9%, 60.0% and 46.5%, respectively. In multivariable regression analysis, compared to patients with pathology confirmed endometriosis, depression was independently associated with patients with SENP (aOR 2.30 95%CI 1.03-5.17). Anxiety alone or the combination of anxiety and/or depression were not independently associated with any of the study groups.</div></div><div><h3>Conclusion</h3><div>Patients with pain symptoms indicative of endometriosis and negative pathology have increased risk of depression, and comparable risk of anxiety compared to patients with pathology confirmed endometriosis. Long-term follow-up of SENP patients will be valuable to determine outcomes for this group of patients, and to optimize the best strategies for clinical care.</div></div>","PeriodicalId":16397,"journal":{"name":"Journal of minimally invasive gynecology","volume":"32 11","pages":"Pages S25-S26"},"PeriodicalIF":3.3000,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Association between Pathology Confirmed Versus Unconfirmed Endometriosis and Anxiety and Depression\",\"authors\":\"K Lawrenson , N Ngo , S Taing , M Liang , A Manlinguez , R Meyer\",\"doi\":\"10.1016/j.jmig.2025.09.033\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Study Objective</h3><div>Among patients with endometriosis, disease symptoms associate poorly with lesion burden, and severe symptoms of endometriosis can occur in patients in whom lesions cannot be detected by pathologic examination. Anxiety and depression are prevalent in patients with confirmed endometriosis. This study aimed to examine these comorbid traits in patients with endometriosis-like symptoms in the absence of a confirmed diagnosis.</div></div><div><h3>Design</h3><div>A prospective study. We collected data from patients who underwent surgery for endometriosis and controls who underwent surgery for other indications between 10/2019 and 3/2024, as part of The Biologic and Epidemiologic Markers of Endometriosis (BEME) clinic-based study.</div></div><div><h3>Setting</h3><div>Quaternary level hospital.</div></div><div><h3>Patients or Participants</h3><div>We compared patients with pathology confirmed endometriosis to patients with suspected endometriosis and negative pathology (SENP) and controls.</div></div><div><h3>Interventions</h3><div>Multivariable regressions analysis to evaluate the association between pathology confirmed endometriosis and medically treated anxiety and/or depression.</div></div><div><h3>Measurements and Primary Results</h3><div>454 women were included in the study, of which 308 (67.8%) had pathology confirmed endometriosis, 45 (9.9%) had SENP, and 101 (22.2%) were controls without endometriosis. The proportion of depression among patients with pathology confirmed endometriosis, SENP and controls 42.4%, 60.0% and 40.6%, respectively. The proportion of anxiety among the groups was 52.9%, 60.0% and 46.5%, respectively. In multivariable regression analysis, compared to patients with pathology confirmed endometriosis, depression was independently associated with patients with SENP (aOR 2.30 95%CI 1.03-5.17). Anxiety alone or the combination of anxiety and/or depression were not independently associated with any of the study groups.</div></div><div><h3>Conclusion</h3><div>Patients with pain symptoms indicative of endometriosis and negative pathology have increased risk of depression, and comparable risk of anxiety compared to patients with pathology confirmed endometriosis. Long-term follow-up of SENP patients will be valuable to determine outcomes for this group of patients, and to optimize the best strategies for clinical care.</div></div>\",\"PeriodicalId\":16397,\"journal\":{\"name\":\"Journal of minimally invasive gynecology\",\"volume\":\"32 11\",\"pages\":\"Pages S25-S26\"},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2025-10-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of minimally invasive gynecology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S155346502500370X\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"OBSTETRICS & GYNECOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of minimally invasive gynecology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S155346502500370X","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

研究目的在子宫内膜异位症患者中，疾病症状与病变负担相关性较差，病理检查未发现病变的患者可出现严重的子宫内膜异位症症状。焦虑和抑郁在确诊的子宫内膜异位症患者中普遍存在。本研究旨在检查在没有确诊的子宫内膜异位症样症状患者的这些合并症特征。设计前瞻性研究。作为子宫内膜异位症生物学和流行病学标志物（BEME）临床研究的一部分，我们收集了2019年10月至2024年3月期间接受子宫内膜异位症手术的患者和接受其他适应症手术的对照组的数据。单位：四级医院。患者或参与者我们将病理确诊的子宫内膜异位症患者与疑似子宫内膜异位症且病理阴性（SENP）的患者和对照组进行比较。干预：采用多变量回归分析评估病理证实的子宫内膜异位症与药物治疗的焦虑和/或抑郁之间的关系。454名妇女纳入研究，其中308名（67.8%）有病理证实的子宫内膜异位症，45名（9.9%）有SENP， 101名（22.2%）为无子宫内膜异位症的对照组。病理确诊的子宫内膜异位症患者、SENP患者和对照组患者中抑郁症占比分别为42.4%、60.0%和40.6%。焦虑的比例分别为52.9%、60.0%和46.5%。在多变量回归分析中，与病理证实的子宫内膜异位症患者相比，抑郁与SENP患者独立相关（aOR 2.30 95%CI 1.03-5.17）。单独的焦虑或焦虑和/或抑郁的组合与任何研究组都没有独立的关联。结论与病理证实的子宫内膜异位症患者相比，伴有疼痛症状的子宫内膜异位症患者抑郁风险增加，焦虑风险相当。SENP患者的长期随访对于确定该组患者的预后和优化临床护理的最佳策略是有价值的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

The Association between Pathology Confirmed Versus Unconfirmed Endometriosis and Anxiety and Depression

Study Objective

Among patients with endometriosis, disease symptoms associate poorly with lesion burden, and severe symptoms of endometriosis can occur in patients in whom lesions cannot be detected by pathologic examination. Anxiety and depression are prevalent in patients with confirmed endometriosis. This study aimed to examine these comorbid traits in patients with endometriosis-like symptoms in the absence of a confirmed diagnosis.

Design

A prospective study. We collected data from patients who underwent surgery for endometriosis and controls who underwent surgery for other indications between 10/2019 and 3/2024, as part of The Biologic and Epidemiologic Markers of Endometriosis (BEME) clinic-based study.

Setting

Quaternary level hospital.

Patients or Participants

We compared patients with pathology confirmed endometriosis to patients with suspected endometriosis and negative pathology (SENP) and controls.

Interventions

Multivariable regressions analysis to evaluate the association between pathology confirmed endometriosis and medically treated anxiety and/or depression.

Measurements and Primary Results

454 women were included in the study, of which 308 (67.8%) had pathology confirmed endometriosis, 45 (9.9%) had SENP, and 101 (22.2%) were controls without endometriosis. The proportion of depression among patients with pathology confirmed endometriosis, SENP and controls 42.4%, 60.0% and 40.6%, respectively. The proportion of anxiety among the groups was 52.9%, 60.0% and 46.5%, respectively. In multivariable regression analysis, compared to patients with pathology confirmed endometriosis, depression was independently associated with patients with SENP (aOR 2.30 95%CI 1.03-5.17). Anxiety alone or the combination of anxiety and/or depression were not independently associated with any of the study groups.

Conclusion

Patients with pain symptoms indicative of endometriosis and negative pathology have increased risk of depression, and comparable risk of anxiety compared to patients with pathology confirmed endometriosis. Long-term follow-up of SENP patients will be valuable to determine outcomes for this group of patients, and to optimize the best strategies for clinical care.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of minimally invasive gynecology 医学-妇产科学

CiteScore

5.00

自引率

7.30%

发文量

272

审稿时长

37 days

期刊介绍： The Journal of Minimally Invasive Gynecology, formerly titled The Journal of the American Association of Gynecologic Laparoscopists, is an international clinical forum for the exchange and dissemination of ideas, findings and techniques relevant to gynecologic endoscopy and other minimally invasive procedures. The Journal, which presents research, clinical opinions and case reports from the brightest minds in gynecologic surgery, is an authoritative source informing practicing physicians of the latest, cutting-edge developments occurring in this emerging field.