Lloyd D Murphy, Saeed Akkad, Angelo Lopez, Morgan E Batiste-Simms, Greg L McNeil, Eva W Wan, Kathryn E Huxley, Luke Julyan, Mia Shandell, Lianne I Willems
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Alkyne-tagged ribitol-5-phosphate derivatives for metabolic labelling of alpha-dystroglycan.
The glycoprotein α-dystroglycan is essential in establishing cell-matrix interactions and is implicated in the pathology of muscular dystrophies. Novel tools are needed to study its rare and intriguing O-mannosyl glycans. This report describes the synthesis and evaluation of alkyne-tagged ribitol-5-phosphate derivatives for the metabolic labelling of α-dystroglycan in mammalian cells.
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