{"title":"肺康复可改善老年非手术NSCLC患者的肺功能和运动耐量。","authors":"Can Ao, Lu Zhan","doi":"10.62347/ZGQU3222","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the clinical efficacy and safety of pulmonary rehabilitation exercise training in improving lung function, exercise tolerance, cancer-related fatigue, and quality of life in elderly patients with non-surgical non-small cell lung cancer (NSCLC).</p><p><strong>Methods: </strong>A total of 186 elderly NSCLC patients who received non-surgical treatment at The First Affiliated Hospital of Chongqing Medical and Pharmaceutical College from April 2023 to October 2024 were retrospectively enrolled. Among them, 95 received routine treatment (control group), and 91 received pulmonary rehabilitation training in addition to routine treatment (rehabilitation group). The intervention lasted 8 weeks. Evaluation indicators included lung function, exercise tolerance, respiratory function, cancer-related fatigue, quality of life, negative emotions, and sleep quality. Adverse reactions were also recorded.</p><p><strong>Results: </strong>By week 4, the social and emotional function in the EORTC QLQ-C30 showed no significant improvement, but by week 8, the rehabilitation group exhibited significantly better outcomes than the control group. Moreover, the rehabilitation group demonstrated significantly greater improvements in lung function, exercise tolerance, respiratory symptoms, cancer-related fatigue, and psychological status than the control group at week 8 (<i>P</i><0.05). In addition, the incidence of adverse reactions in the rehabilitation group was significantly lower (<i>P</i><0.05).</p><p><strong>Conclusion: </strong>Pulmonary rehabilitation training can effectively improve lung function and exercise capacity in elderly non-surgical NSCLC patients, alleviate fatigue and anxiety, enhance quality of life, and is safe for clinical application.</p>","PeriodicalId":7437,"journal":{"name":"American journal of cancer research","volume":"15 9","pages":"4029-4042"},"PeriodicalIF":2.9000,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12531293/pdf/","citationCount":"0","resultStr":"{\"title\":\"Pulmonary rehabilitation improves lung function and exercise tolerance in elderly non-surgical NSCLC patients.\",\"authors\":\"Can Ao, Lu Zhan\",\"doi\":\"10.62347/ZGQU3222\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To evaluate the clinical efficacy and safety of pulmonary rehabilitation exercise training in improving lung function, exercise tolerance, cancer-related fatigue, and quality of life in elderly patients with non-surgical non-small cell lung cancer (NSCLC).</p><p><strong>Methods: </strong>A total of 186 elderly NSCLC patients who received non-surgical treatment at The First Affiliated Hospital of Chongqing Medical and Pharmaceutical College from April 2023 to October 2024 were retrospectively enrolled. Among them, 95 received routine treatment (control group), and 91 received pulmonary rehabilitation training in addition to routine treatment (rehabilitation group). The intervention lasted 8 weeks. Evaluation indicators included lung function, exercise tolerance, respiratory function, cancer-related fatigue, quality of life, negative emotions, and sleep quality. Adverse reactions were also recorded.</p><p><strong>Results: </strong>By week 4, the social and emotional function in the EORTC QLQ-C30 showed no significant improvement, but by week 8, the rehabilitation group exhibited significantly better outcomes than the control group. Moreover, the rehabilitation group demonstrated significantly greater improvements in lung function, exercise tolerance, respiratory symptoms, cancer-related fatigue, and psychological status than the control group at week 8 (<i>P</i><0.05). In addition, the incidence of adverse reactions in the rehabilitation group was significantly lower (<i>P</i><0.05).</p><p><strong>Conclusion: </strong>Pulmonary rehabilitation training can effectively improve lung function and exercise capacity in elderly non-surgical NSCLC patients, alleviate fatigue and anxiety, enhance quality of life, and is safe for clinical application.</p>\",\"PeriodicalId\":7437,\"journal\":{\"name\":\"American journal of cancer research\",\"volume\":\"15 9\",\"pages\":\"4029-4042\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2025-09-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12531293/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"American journal of cancer research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.62347/ZGQU3222\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"American journal of cancer research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.62347/ZGQU3222","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}
Pulmonary rehabilitation improves lung function and exercise tolerance in elderly non-surgical NSCLC patients.
Objective: To evaluate the clinical efficacy and safety of pulmonary rehabilitation exercise training in improving lung function, exercise tolerance, cancer-related fatigue, and quality of life in elderly patients with non-surgical non-small cell lung cancer (NSCLC).
Methods: A total of 186 elderly NSCLC patients who received non-surgical treatment at The First Affiliated Hospital of Chongqing Medical and Pharmaceutical College from April 2023 to October 2024 were retrospectively enrolled. Among them, 95 received routine treatment (control group), and 91 received pulmonary rehabilitation training in addition to routine treatment (rehabilitation group). The intervention lasted 8 weeks. Evaluation indicators included lung function, exercise tolerance, respiratory function, cancer-related fatigue, quality of life, negative emotions, and sleep quality. Adverse reactions were also recorded.
Results: By week 4, the social and emotional function in the EORTC QLQ-C30 showed no significant improvement, but by week 8, the rehabilitation group exhibited significantly better outcomes than the control group. Moreover, the rehabilitation group demonstrated significantly greater improvements in lung function, exercise tolerance, respiratory symptoms, cancer-related fatigue, and psychological status than the control group at week 8 (P<0.05). In addition, the incidence of adverse reactions in the rehabilitation group was significantly lower (P<0.05).
Conclusion: Pulmonary rehabilitation training can effectively improve lung function and exercise capacity in elderly non-surgical NSCLC patients, alleviate fatigue and anxiety, enhance quality of life, and is safe for clinical application.
期刊介绍：
The American Journal of Cancer Research (AJCR) (ISSN 2156-6976), is an independent open access, online only journal to facilitate rapid dissemination of novel discoveries in basic science and treatment of cancer. It was founded by a group of scientists for cancer research and clinical academic oncologists from around the world, who are devoted to the promotion and advancement of our understanding of the cancer and its treatment. The scope of AJCR is intended to encompass that of multi-disciplinary researchers from any scientific discipline where the primary focus of the research is to increase and integrate knowledge about etiology and molecular mechanisms of carcinogenesis with the ultimate aim of advancing the cure and prevention of this increasingly devastating disease. To achieve these aims AJCR will publish review articles, original articles and new techniques in cancer research and therapy. It will also publish hypothesis, case reports and letter to the editor. Unlike most other open access online journals, AJCR will keep most of the traditional features of paper print that we are all familiar with, such as continuous volume, issue numbers, as well as continuous page numbers to retain our comfortable familiarity towards an academic journal.
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