Erlane da Rocha Fernandes, Jefferson Henrique Tiago Barros, Patrícia Martins Guarda, Emerson Adriano Guarda
{"title":"离子液体和深共晶溶剂在提取具有生物活性的植物化学物质中的应用综述","authors":"Erlane da Rocha Fernandes, Jefferson Henrique Tiago Barros, Patrícia Martins Guarda, Emerson Adriano Guarda","doi":"10.1007/s11483-025-10037-0","DOIUrl":null,"url":null,"abstract":"<div><p>Innovative solvents like Ionic Liquids (ILs), Deep Eutectic Solvents (DES), and more recently, Natural Deep Eutectic Solvents (NaDES) have emerged as promising alternatives to conventional organic solvents for the extraction of bioactive compounds from plants. These solvents have gained attention due to their efficiency, lower environmental impact, and potential to enhance the selectivity of target compound extraction. Despite significant advancements in this field, a literature review revealed a lack of systematic reviews on the application of these solvents in plant bioactive extraction, over the past five years. Therefore, this study aims to compare ILs, DES, and NaDES in terms of efficiency, applicability, usability, and environmental impact, providing a comprehensive overview of the trends and challenges in this emerging field. The PRISMA methodology was used for article selection, resulting in a total of 77 studies analyzed. The findings indicate a growing number of studies on the use of DES and NaDES, whereas research on ILs for this purpose remains relatively scarce within the investigated period. Furthermore, an increasing trend in combined extraction methods was observed, with a particular emphasis on ultrasound-assisted extraction (UAE) and microwave-assisted extraction (MAE), which have shown promising effects when used alongside these solvents to enhance bioactive compound extraction. This review contributes to a deeper understanding of the emerging role of DES and NaDES in plant bioactive extraction and highlights the need for further investigations on ILs, particularly within the context of sustainable and cost-effective extraction methodologies.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":564,"journal":{"name":"Food Biophysics","volume":"20 4","pages":""},"PeriodicalIF":3.2000,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Use of Ionic Liquids and Deep Eutectic Solvents in the Extraction of Phytochemicals with Bioactive Properties: A Review\",\"authors\":\"Erlane da Rocha Fernandes, Jefferson Henrique Tiago Barros, Patrícia Martins Guarda, Emerson Adriano Guarda\",\"doi\":\"10.1007/s11483-025-10037-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Innovative solvents like Ionic Liquids (ILs), Deep Eutectic Solvents (DES), and more recently, Natural Deep Eutectic Solvents (NaDES) have emerged as promising alternatives to conventional organic solvents for the extraction of bioactive compounds from plants. These solvents have gained attention due to their efficiency, lower environmental impact, and potential to enhance the selectivity of target compound extraction. Despite significant advancements in this field, a literature review revealed a lack of systematic reviews on the application of these solvents in plant bioactive extraction, over the past five years. Therefore, this study aims to compare ILs, DES, and NaDES in terms of efficiency, applicability, usability, and environmental impact, providing a comprehensive overview of the trends and challenges in this emerging field. The PRISMA methodology was used for article selection, resulting in a total of 77 studies analyzed. The findings indicate a growing number of studies on the use of DES and NaDES, whereas research on ILs for this purpose remains relatively scarce within the investigated period. Furthermore, an increasing trend in combined extraction methods was observed, with a particular emphasis on ultrasound-assisted extraction (UAE) and microwave-assisted extraction (MAE), which have shown promising effects when used alongside these solvents to enhance bioactive compound extraction. This review contributes to a deeper understanding of the emerging role of DES and NaDES in plant bioactive extraction and highlights the need for further investigations on ILs, particularly within the context of sustainable and cost-effective extraction methodologies.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>\",\"PeriodicalId\":564,\"journal\":{\"name\":\"Food Biophysics\",\"volume\":\"20 4\",\"pages\":\"\"},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2025-10-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Food Biophysics\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s11483-025-10037-0\",\"RegionNum\":4,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"FOOD SCIENCE & TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Food Biophysics","FirstCategoryId":"97","ListUrlMain":"https://link.springer.com/article/10.1007/s11483-025-10037-0","RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}
The Use of Ionic Liquids and Deep Eutectic Solvents in the Extraction of Phytochemicals with Bioactive Properties: A Review
Innovative solvents like Ionic Liquids (ILs), Deep Eutectic Solvents (DES), and more recently, Natural Deep Eutectic Solvents (NaDES) have emerged as promising alternatives to conventional organic solvents for the extraction of bioactive compounds from plants. These solvents have gained attention due to their efficiency, lower environmental impact, and potential to enhance the selectivity of target compound extraction. Despite significant advancements in this field, a literature review revealed a lack of systematic reviews on the application of these solvents in plant bioactive extraction, over the past five years. Therefore, this study aims to compare ILs, DES, and NaDES in terms of efficiency, applicability, usability, and environmental impact, providing a comprehensive overview of the trends and challenges in this emerging field. The PRISMA methodology was used for article selection, resulting in a total of 77 studies analyzed. The findings indicate a growing number of studies on the use of DES and NaDES, whereas research on ILs for this purpose remains relatively scarce within the investigated period. Furthermore, an increasing trend in combined extraction methods was observed, with a particular emphasis on ultrasound-assisted extraction (UAE) and microwave-assisted extraction (MAE), which have shown promising effects when used alongside these solvents to enhance bioactive compound extraction. This review contributes to a deeper understanding of the emerging role of DES and NaDES in plant bioactive extraction and highlights the need for further investigations on ILs, particularly within the context of sustainable and cost-effective extraction methodologies.
期刊介绍：
Biophysical studies of foods and agricultural products involve research at the interface of chemistry, biology, and engineering, as well as the new interdisciplinary areas of materials science and nanotechnology. Such studies include but are certainly not limited to research in the following areas: the structure of food molecules, biopolymers, and biomaterials on the molecular, microscopic, and mesoscopic scales; the molecular basis of structure generation and maintenance in specific foods, feeds, food processing operations, and agricultural products; the mechanisms of microbial growth, death and antimicrobial action; structure/function relationships in food and agricultural biopolymers; novel biophysical techniques (spectroscopic, microscopic, thermal, rheological, etc.) for structural and dynamical characterization of food and agricultural materials and products; the properties of amorphous biomaterials and their influence on chemical reaction rate, microbial growth, or sensory properties; and molecular mechanisms of taste and smell.
A hallmark of such research is a dependence on various methods of instrumental analysis that provide information on the molecular level, on various physical and chemical theories used to understand the interrelations among biological molecules, and an attempt to relate macroscopic chemical and physical properties and biological functions to the molecular structure and microscopic organization of the biological material.
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