急性胰腺炎患者“再发”糖尿病的发生率及其与预后和严重程度的关系

IF 2.7 3区医学 Q1 SURGERY

American journal of surgery Pub Date : 2025-10-10 DOI:10.1016/j.amjsurg.2025.116663

Prishita Banerji, Yajjat Garg

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引用次数: 0

摘要

简介：急性胰腺炎（AP）可因胰腺内分泌功能紊乱而发展为新生糖尿病（DM）。该并发症的发生率和危险因素仍未得到充分研究。目的：评价急性胰腺炎患者新发糖尿病的发生率及其与疾病严重程度的关系。方法：对2022年1月至2023年12月住院的91例AP患者进行回顾性队列研究。2024年1月至11月的随访评估了de-novo DM的发展情况。结果：de-novo DM发生39例（42%），中位年龄54岁。严重AP发生率为43%，其中31%需要ICU护理，6.5%接受了坏死切除术。4名患者死亡。在糖尿病患者中，67%需要胰岛素，28%需要口服药物，5%需要停止治疗。结论：新生糖尿病是AP常见且严重的后果，疾病严重程度与糖尿病的发展和结局密切相关。

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The incidence of “de-novo” diabetes mellitus in patients with acute pancreatitis and its association with outcome and severity

Introduction

Acute pancreatitis (AP) may lead to the development of de-novo diabetes mellitus (DM) due to pancreatic endocrine dysfunction. The incidence and risk factors for this complication remain under-investigated.

Aim

To evaluate the incidence of de-novo DM in patients with AP and its association with disease severity.

Methods

A retrospective cohort study of 91 patients hospitalised with AP from January 2022 to December 2023 was conducted. Follow-up from January to November 2024 evaluated the development of de-novo DM.

Results

De-novo DM occurred in 39 patients (42 %), with a median age of 54 years. Severe AP was observed in 43 %, 31 % of whom required ICU care and 6.5 % underwent necrosectomy. Four patients died. Among DM cases, 67 % required insulin, 28 % oral medication, and 5 % discontinued treatment.

Conclusion

De-novo DM is a common and serious consequence of AP. Disease severity strongly correlates with diabetes development and outcomes.

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来源期刊

American journal of surgery 医学-外科

CiteScore

5.00

自引率

6.70%

发文量

570

审稿时长

56 days

期刊介绍： The American Journal of Surgery® is a peer-reviewed journal designed for the general surgeon who performs abdominal, cancer, vascular, head and neck, breast, colorectal, and other forms of surgery. AJS is the official journal of 7 major surgical societies* and publishes their official papers as well as independently submitted clinical studies, editorials, reviews, brief reports, correspondence and book reviews.