白蛋白偶联对顺铂、奥沙利铂和金嘌呤在癌细胞中的细胞毒性的影响

IF 6.4 1区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR

Inorganic Chemistry Frontiers Pub Date : 2025-10-17 DOI:10.1039/d5qi01487e

Valentina Vitali, Lorenzo Chiaverini, Mirko Severi, Maria Letizia Trincavelli, Luigi Messori, Lara Massai, Tiziano Marzo, Chiara Giacomelli

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引用次数: 0

摘要

人血清白蛋白（HSA）在抗癌金属药物传递中的作用尚不清楚，需要进一步研究。为此，制备了HSA与金属药物顺铂（CIS）、奥沙利铂（OXA）和金嘌呤（AF）的生物偶联物，用ESI-MS和ICP进行了表征，并在A2780和HCT116癌细胞中检测了它们的细胞毒性。与Au生物偶联物相比，两种Pt生物偶联物的生物活性存在显着差异，这些差异在现有文献的背景下进行了解释和讨论。

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The impact of albumin conjugation on the cytotoxic properties of cisplatin, oxaliplatin and auranofin in cancer cells

The role of human serum albumin (HSA) in the delivery of anticancer metallodrugs remains unclear and requires further investigation. To this end, bioconjugates of HSA with the metallodrugs cisplatin (CIS), oxaliplatin (OXA) and auranofin (AF) were prepared, characterised by ESI-MS and ICP, and tested for their cytotoxic properties in A2780 and HCT116 cancer cells. Significant differences in the biological activity of the two Pt bioconjugates compared to the Au bioconjugate emerged, which are interpreted and discussed in the context of the available literature.

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