{"title":"全肿瘤表观扩散系数直方图分析在R-ISS II期多发性骨髓瘤患者预后分层中的应用。","authors":"Junde Zhou, Qin Wang, Yanting Liu, Lu Zhang, Jiao Li, Shuo Li, Dong Liu, Jinxia Zhu, Robert Grimm, Alto Stemmer, Shuang Xia, Wenyang Huang, Sheng Xie, Haibo Zhang, Jian Li, Huadan Xue, Zhengyu Jin","doi":"10.1016/j.mri.2025.110536","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to explore the utility of total tumor apparent diffusion coefficient (ttADC) histogram analysis based on whole-body diffusion-weighted magnetic resonance imaging (DWI-MRI) for prognostic stratification in patients with Revised International Staging System stage II (R-ISS II) multiple myeloma (MM).</p><p><strong>Methods: </strong>Patients with R-ISS II MM who underwent baseline whole-body MRI prior to treatment were retrospectively enrolled. The ttADC histogram parameters of the whole-body DWI-MRI were obtained using MR Total Tumor Load software (Siemens Healthcare, Erlangen, Germany). The overall survival (OS) and the progression-free survival (PFS) of the cohort was recorded. Cox regression analyses were used to evaluate the clinical features and ttADC histogram parameters for their association with OS and PFS.</p><p><strong>Results: </strong>A total of 61 R-ISS II MM patients were retrospectively included. During a mean follow-up period of 80 months, 27 patients died, 4 patients lost follow-up for OS, and 4 patients lost follow-up for PFS. Multivariate analysis revealed that increased median ttADC (≥0.620 × 10<sup>-3</sup> mm<sup>2</sup>/s) [hazard ratio (HR) = 2.291, P = 0.046, 95 % confidence interval (CI): 1.014-5.175] was independently associated with OS in R-ISS II MM patients. No significant association was observed between the ttADC histogram parameters and PFS.</p><p><strong>Conclusion: </strong>The median ttADC of whole-body DWI-MRI is an independent predictor of OS in R-ISS II MM patients, suggesting its potential role in further prognostic stratification in this patients' subgroup.</p>","PeriodicalId":18165,"journal":{"name":"Magnetic resonance imaging","volume":" ","pages":"110536"},"PeriodicalIF":2.0000,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Total tumor apparent diffusion coefficient histogram analysis of whole-body DWI-MRI for prognostic stratification in patients with R-ISS stage II multiple myeloma.\",\"authors\":\"Junde Zhou, Qin Wang, Yanting Liu, Lu Zhang, Jiao Li, Shuo Li, Dong Liu, Jinxia Zhu, Robert Grimm, Alto Stemmer, Shuang Xia, Wenyang Huang, Sheng Xie, Haibo Zhang, Jian Li, Huadan Xue, Zhengyu Jin\",\"doi\":\"10.1016/j.mri.2025.110536\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>This study aimed to explore the utility of total tumor apparent diffusion coefficient (ttADC) histogram analysis based on whole-body diffusion-weighted magnetic resonance imaging (DWI-MRI) for prognostic stratification in patients with Revised International Staging System stage II (R-ISS II) multiple myeloma (MM).</p><p><strong>Methods: </strong>Patients with R-ISS II MM who underwent baseline whole-body MRI prior to treatment were retrospectively enrolled. The ttADC histogram parameters of the whole-body DWI-MRI were obtained using MR Total Tumor Load software (Siemens Healthcare, Erlangen, Germany). The overall survival (OS) and the progression-free survival (PFS) of the cohort was recorded. Cox regression analyses were used to evaluate the clinical features and ttADC histogram parameters for their association with OS and PFS.</p><p><strong>Results: </strong>A total of 61 R-ISS II MM patients were retrospectively included. During a mean follow-up period of 80 months, 27 patients died, 4 patients lost follow-up for OS, and 4 patients lost follow-up for PFS. Multivariate analysis revealed that increased median ttADC (≥0.620 × 10<sup>-3</sup> mm<sup>2</sup>/s) [hazard ratio (HR) = 2.291, P = 0.046, 95 % confidence interval (CI): 1.014-5.175] was independently associated with OS in R-ISS II MM patients. No significant association was observed between the ttADC histogram parameters and PFS.</p><p><strong>Conclusion: </strong>The median ttADC of whole-body DWI-MRI is an independent predictor of OS in R-ISS II MM patients, suggesting its potential role in further prognostic stratification in this patients' subgroup.</p>\",\"PeriodicalId\":18165,\"journal\":{\"name\":\"Magnetic resonance imaging\",\"volume\":\" \",\"pages\":\"110536\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-10-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Magnetic resonance imaging\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.mri.2025.110536\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Magnetic resonance imaging","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.mri.2025.110536","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
Total tumor apparent diffusion coefficient histogram analysis of whole-body DWI-MRI for prognostic stratification in patients with R-ISS stage II multiple myeloma.
Purpose: This study aimed to explore the utility of total tumor apparent diffusion coefficient (ttADC) histogram analysis based on whole-body diffusion-weighted magnetic resonance imaging (DWI-MRI) for prognostic stratification in patients with Revised International Staging System stage II (R-ISS II) multiple myeloma (MM).
Methods: Patients with R-ISS II MM who underwent baseline whole-body MRI prior to treatment were retrospectively enrolled. The ttADC histogram parameters of the whole-body DWI-MRI were obtained using MR Total Tumor Load software (Siemens Healthcare, Erlangen, Germany). The overall survival (OS) and the progression-free survival (PFS) of the cohort was recorded. Cox regression analyses were used to evaluate the clinical features and ttADC histogram parameters for their association with OS and PFS.
Results: A total of 61 R-ISS II MM patients were retrospectively included. During a mean follow-up period of 80 months, 27 patients died, 4 patients lost follow-up for OS, and 4 patients lost follow-up for PFS. Multivariate analysis revealed that increased median ttADC (≥0.620 × 10-3 mm2/s) [hazard ratio (HR) = 2.291, P = 0.046, 95 % confidence interval (CI): 1.014-5.175] was independently associated with OS in R-ISS II MM patients. No significant association was observed between the ttADC histogram parameters and PFS.
Conclusion: The median ttADC of whole-body DWI-MRI is an independent predictor of OS in R-ISS II MM patients, suggesting its potential role in further prognostic stratification in this patients' subgroup.
期刊介绍：
Magnetic Resonance Imaging (MRI) is the first international multidisciplinary journal encompassing physical, life, and clinical science investigations as they relate to the development and use of magnetic resonance imaging. MRI is dedicated to both basic research, technological innovation and applications, providing a single forum for communication among radiologists, physicists, chemists, biochemists, biologists, engineers, internists, pathologists, physiologists, computer scientists, and mathematicians.
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