nhc催化[3+3]环化的2-吡喃酮-类螺旋选择组装

IF 4.7 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Chemistry Frontiers Pub Date : 2025-10-17 DOI:10.1039/d5qo01328c

Jiahui jian wang, shujie Ji, Zhipeng Li, Yuhan Liu, Yani Li, Jian Wang

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引用次数: 0

摘要

螺旋结构在超分子化学和材料科学中起着至关重要的作用。然而，缺乏强大的立体选择方法继续阻碍其实际发展。本文报道了一种nhc催化的螺旋选择[3+3]环化方法，用于手性2-吡喃酮融合螺旋萜类化合物的组装。该工艺使非手性起始原料转化为手性2-吡喃酮-螺旋萜类化合物，产率从高到高，对映选择性从高到优异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Helicoselective Assembly of 2-Pyranone-Helicenoids via NHC-Catalyzed [3+3] Annulation

Helical frameworks play a vital role in supramolecular chemistry and material sciences. Nevertheless, the scarcity of robust stereoselective methodologies continues to impede their practical development. We herein report an NHC-catalyzed helicoselective [3+3] annulation approach for the assembly of chiral 2-pyranone fused helicenoids. This protocol enables the conversion of achiral starting materials into chiral 2-pyranone-helicenoids with good to high yields, and high to excellent enantioselectivities.

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来源期刊

Organic Chemistry Frontiers CHEMISTRY, ORGANIC-

CiteScore

7.90

自引率

11.10%

发文量

686

审稿时长

1 months

期刊介绍： Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.