免疫原性细胞死亡诱导Rh(I)和Ir(I)配合物与双（亚氨基）苊衍生配体：洞察金属中心和配体的作用

IF 6.4 1区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR

Inorganic Chemistry Frontiers Pub Date : 2025-10-17 DOI:10.1039/d5qi00868a

Chengnan Wu, Nikolay Filippovich Romashev, Veronica I. Komlyagina, Tamara Petrović, Ivan V. Bakaev, Pavel A. Abramov, Yuan Wang, Alexey A. Ryadun, Iakov S. Fomenko, Taotao Zou, Artem Gushchin, Maria V Babak

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引用次数: 0

摘要

虽然各种金属配合物具有诱导免疫原性细胞死亡（ICD）的特性，但缺乏比较结构相似但具有不同金属中心的配合物的ICD特性的研究。在这项研究中，我们合成了四种结构相似的具有氧化还原活性的1,2-双（芳基）苊（Ar-bian）配体的Rh(I)和Ir(I)配合物，并评估了它们的抗癌和诱导icd的性能。对危险相关分子模式（DAMPs）和死亡细胞群的分析强调了金属中心的独特作用，而配体的贡献则不那么明显。具体来说，只有Rh(I)复合物诱导了三种必需的DAMPs的释放和高水平的晚期凋亡细胞，而Ir(I)复合物未能触发关键的“吃我”信号。这项工作为理解ICD背景下金属配合物的构效关系提供了有价值的见解。

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Immunogenic cell death-inducing Rh(I) and Ir(I) complexes with bis(imino)acenaphthene-derived ligands: Insights into the role of the metal center and the ligands

While various metal complexes demonstrated immunogenic cell death (ICD)-inducing properties, there is a lack of studies comparing ICD properties in structurally similar complexes with different metal centers. In this study, we synthesized four structurally similar Rh(I) and Ir(I) complexes with redox-active 1,2-bis(arylimino)acenaphthene (Ar-bian) ligands and assessed their anticancer and ICD-inducing properties. Analysis of danger-associated molecular patterns (DAMPs) and dying cell populations highlighted the distinct role of the metal center, with the contribution of the ligand being less evident. Specifically, only Rh(I) complexes induced the release of the three essential DAMPs and high levels of late apoptotic cells, while the Ir(I) complexes failed to trigger crucial "eat-me" signals. This work offers valuable insights into understanding of structure-activity relationships in metal complexes in the context of ICD.

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