靶向金属凋亡在肿瘤治疗中的应用：从分子机制到金属纳米颗粒的应用

IF 33.9 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Cancer Pub Date : 2025-10-16 DOI:10.1186/s12943-025-02414-7

Jinxiang Wang, Qin Tian, Yuchen Liu, Chao-Yun Cai, Shuying Fu, Jia Li, Yupeng Guan, Xuankai Liao, Danting Su, Tuanwei Sun, Yong Zhang, Rubing Lin, Yuzhi Xu, Jun Pang, Leli Zeng, Yihang Pan

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引用次数: 0

摘要

金属离子调控细胞死亡（RCD）是一种涉及金属离子并受一个或多个级联信号通路控制的细胞死亡形式，最近被称为“金属凋亡”。鉴于人们对金属下垂在恶性进展中的认识和纳米治疗方法的快速发展，本文综述了金属下垂的最新进展，重点介绍了各种金属离子的作用和金属下垂在癌症治疗和纳米医学中的靶向作用。我们简要介绍了RCD的主要发现，并全面总结了目前新兴金属坏死形式的主要调控信号通路，包括铁下垂、铜下垂、溶锌下垂、锰中毒、钙衰和钠过载坏死（NECSO）。此外，我们证明了金属下垂对恶性肿瘤进展和肿瘤微环境（TME）的影响。此外，我们还讨论了利用金属纳米颗粒（MNPs）靶向金属凋亡途径治疗癌症和克服癌细胞耐药的可行性。我们希望这篇综述将为利用金属下垂在精确肿瘤学中提供基础见解和转化前景。

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Targeting metalloptosis in tumor therapy: from molecular mechanisms to application of metal nanoparticles

Metal ions-based regulated cell death (RCD), a form of cell death involving metal ions and controlled by one or more cascade signaling pathways, has recently been termed “metalloptosis”. Given the rapid advances in understanding metalloptosis in malignant progression and nanotherapeutics, this review elucidates the latest progress in metalloptosis, focusing on the roles of various metal ions and the targeting of metalloptosis in cancer therapy and nanomedicine. We briefly describe the essential discoveries of RCD and comprehensively summarize the current major regulatory signaling pathways of emerging metalloptosis forms, including ferroptosis, cuproptosis, lysozincrosis, manganism, calcicoptosis, and necrosis by sodium overload (NECSO). Additionally, we demonstrated the effects of metalloptosis on malignant neoplastic progression and the tumor microenvironment (TME). Furthermore, we discuss the feasibility of targeting metalloptosis pathways using metal nanoparticles (MNPs) for cancer therapy and overcoming drug resistance in cancer cells. We hope that this review will provide both fundamental insights and translational outlooks for harnessing metalloptosis in precision oncology.

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来源期刊

Molecular Cancer 医学-生化与分子生物学

CiteScore

54.90

自引率

2.70%

发文量

224

审稿时长

2 months

期刊介绍： Molecular Cancer is a platform that encourages the exchange of ideas and discoveries in the field of cancer research, particularly focusing on the molecular aspects. Our goal is to facilitate discussions and provide insights into various areas of cancer and related biomedical science. We welcome articles from basic, translational, and clinical research that contribute to the advancement of understanding, prevention, diagnosis, and treatment of cancer. The scope of topics covered in Molecular Cancer is diverse and inclusive. These include, but are not limited to, cell and tumor biology, angiogenesis, utilizing animal models, understanding metastasis, exploring cancer antigens and the immune response, investigating cellular signaling and molecular biology, examining epidemiology, genetic and molecular profiling of cancer, identifying molecular targets, studying cancer stem cells, exploring DNA damage and repair mechanisms, analyzing cell cycle regulation, investigating apoptosis, exploring molecular virology, and evaluating vaccine and antibody-based cancer therapies. Molecular Cancer serves as an important platform for sharing exciting discoveries in cancer-related research. It offers an unparalleled opportunity to communicate information to both specialists and the general public. The online presence of Molecular Cancer enables immediate publication of accepted articles and facilitates the presentation of large datasets and supplementary information. This ensures that new research is efficiently and rapidly disseminated to the scientific community.