Sylvain Bodard, Amirkasra Mojtahed, Madeleine Sertic, Theodore T Pierce, Rory L Cochran, Reece J Goiffon, Leonardo V Riella
{"title":"2例异种肾移植受者的常规和增强超声成像分析。","authors":"Sylvain Bodard, Amirkasra Mojtahed, Madeleine Sertic, Theodore T Pierce, Rory L Cochran, Reece J Goiffon, Leonardo V Riella","doi":"10.1097/TP.0000000000005538","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Kidney xenotransplantation offers a promising novel solution to the global organ shortage, although the expected postoperative imaging characteristics remain undefined.</p><p><strong>Methods: </strong>We report the first application of longitudinal grayscale, color, and spectral Doppler ultrasound in 2 human recipients of genetically engineered porcine kidney xenografts. One recipient additionally underwent serial contrast-enhanced ultrasound to assess parenchymal perfusion. Imaging findings were correlated with serum creatinine trajectories and biopsy-proven rejection.</p><p><strong>Results: </strong>In both recipients, spectral Doppler abnormalities-including elevation in resistive index-preceded biopsy-confirmed T-cell-mediated rejection. Contrast-enhanced ultrasound in 1 recipient revealed delayed contrast enhancement that paralleled rejection and normalized with treatment. Neither graft demonstrated significant posttransplant growth, with observed changes in graft length remaining within the expected range for Yucatan miniature swine-derived kidneys.</p><p><strong>Conclusions: </strong>These findings provide the first preliminary ultrasound-based insights into kidney xenograft vascular dynamics and growth patterns, underscoring the potential of ultrasound as an essential tool for noninvasive monitoring of kidney xenotransplants.</p>","PeriodicalId":23316,"journal":{"name":"Transplantation","volume":" ","pages":""},"PeriodicalIF":5.0000,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Conventional and Contrast-enhanced Ultrasound Imaging in 2 Human Kidney Xenotransplant Recipients.\",\"authors\":\"Sylvain Bodard, Amirkasra Mojtahed, Madeleine Sertic, Theodore T Pierce, Rory L Cochran, Reece J Goiffon, Leonardo V Riella\",\"doi\":\"10.1097/TP.0000000000005538\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Kidney xenotransplantation offers a promising novel solution to the global organ shortage, although the expected postoperative imaging characteristics remain undefined.</p><p><strong>Methods: </strong>We report the first application of longitudinal grayscale, color, and spectral Doppler ultrasound in 2 human recipients of genetically engineered porcine kidney xenografts. One recipient additionally underwent serial contrast-enhanced ultrasound to assess parenchymal perfusion. Imaging findings were correlated with serum creatinine trajectories and biopsy-proven rejection.</p><p><strong>Results: </strong>In both recipients, spectral Doppler abnormalities-including elevation in resistive index-preceded biopsy-confirmed T-cell-mediated rejection. Contrast-enhanced ultrasound in 1 recipient revealed delayed contrast enhancement that paralleled rejection and normalized with treatment. Neither graft demonstrated significant posttransplant growth, with observed changes in graft length remaining within the expected range for Yucatan miniature swine-derived kidneys.</p><p><strong>Conclusions: </strong>These findings provide the first preliminary ultrasound-based insights into kidney xenograft vascular dynamics and growth patterns, underscoring the potential of ultrasound as an essential tool for noninvasive monitoring of kidney xenotransplants.</p>\",\"PeriodicalId\":23316,\"journal\":{\"name\":\"Transplantation\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":5.0000,\"publicationDate\":\"2025-10-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Transplantation\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1097/TP.0000000000005538\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"IMMUNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Transplantation","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/TP.0000000000005538","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
Conventional and Contrast-enhanced Ultrasound Imaging in 2 Human Kidney Xenotransplant Recipients.
Background: Kidney xenotransplantation offers a promising novel solution to the global organ shortage, although the expected postoperative imaging characteristics remain undefined.
Methods: We report the first application of longitudinal grayscale, color, and spectral Doppler ultrasound in 2 human recipients of genetically engineered porcine kidney xenografts. One recipient additionally underwent serial contrast-enhanced ultrasound to assess parenchymal perfusion. Imaging findings were correlated with serum creatinine trajectories and biopsy-proven rejection.
Results: In both recipients, spectral Doppler abnormalities-including elevation in resistive index-preceded biopsy-confirmed T-cell-mediated rejection. Contrast-enhanced ultrasound in 1 recipient revealed delayed contrast enhancement that paralleled rejection and normalized with treatment. Neither graft demonstrated significant posttransplant growth, with observed changes in graft length remaining within the expected range for Yucatan miniature swine-derived kidneys.
Conclusions: These findings provide the first preliminary ultrasound-based insights into kidney xenograft vascular dynamics and growth patterns, underscoring the potential of ultrasound as an essential tool for noninvasive monitoring of kidney xenotransplants.
期刊介绍：
The official journal of The Transplantation Society, and the International Liver Transplantation Society, Transplantation is published monthly and is the most cited and influential journal in the field, with more than 25,000 citations per year.
Transplantation has been the trusted source for extensive and timely coverage of the most important advances in transplantation for over 50 years. The Editors and Editorial Board are an international group of research and clinical leaders that includes many pioneers of the field, representing a diverse range of areas of expertise. This capable editorial team provides thoughtful and thorough peer review, and delivers rapid, careful and insightful editorial evaluation of all manuscripts submitted to the journal.
Transplantation is committed to rapid review and publication. The journal remains competitive with a time to first decision of fewer than 21 days. Transplantation was the first in the field to offer CME credit to its peer reviewers for reviews completed.
The journal publishes original research articles in original clinical science and original basic science. Short reports bring attention to research at the forefront of the field. Other areas covered include cell therapy and islet transplantation, immunobiology and genomics, and xenotransplantation.
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