Heparanase2通过调节VEGF/VEGFR通路抑制胆囊癌的生长。

IF 2.9 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Discover. Oncology Pub Date : 2025-10-15 DOI:10.1007/s12672-025-03696-5

Dengyi Cao, Jiawei Chen, Shaobo Zhou, Jie Tang, Zixiang Liu, Zixiang Zhang

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引用次数: 0

摘要

肝素酶2 （Hpa2）是肝素酶的同源物，缺乏与肝素降解相关的传统肝素酶活性。然而，与肝素酶相比，它对硫酸肝素（HS）具有更大的亲和力。在我们的研究中，过表达Hpa2在体内和体外均能显著抑制胆囊癌细胞的活力、迁移和侵袭。此外，Hpa2的这种抑制作用在施用靶向VEGF/VEGFR通路的激动剂后被逆转。这些发现表明，Hpa2过表达可能通过调节VEGF/VEGFR信号通路阻碍NOZ细胞的生长。

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Heparanase2 inhibits the growth of gallbladder cancer by regulating the VEGF/VEGFR pathway.

Heparanase 2 (Hpa2), a homolog of heparinase, lacks the conventional heparinase activity associated with heparin degradation. However, it exhibits a greater affinity for heparin sulfate (HS) compared to heparinase. In our study, overexpression of Hpa2 significantly inhibited the viability, migration, and invasion of gallbladder cancer cells, both in vivo and in vitro. Moreover, this inhibitory effect of Hpa2 was reversed upon administration of agonists targeting the VEGF/VEGFR pathway. These findings suggest that Hpa2 overexpression may impede the growth of NOZ cells, potentially through modulation of the VEGF/VEGFR signaling pathway.

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