Exploring the Relationship Between Central Sensitization, Pain Characteristics, and Function in a Cross-Sectional Study of Individuals with Lateral Elbow Tendinopathy.

Objective: To investigate the relationship between central sensitization, pain intensity, pain interference, and function in individuals with lateral elbow tendinopathy, and to determine the influence of psychological factors such as anxiety and depression. A cohort study involving comprehensive assessments to explore associations between neurophysiological and psychological factors in lateral elbow tendinopathy patients.

Methods: Participants diagnosed with lateral elbow tendinopathy underwent evaluations including the Central Sensitization Inventory, neurophysiological measures, and psychological assessments (anxiety and depression scales). Pain intensity and interference were measured, along with patient-specific functional scores to assess functional ability.

Results: Elevated Central Sensitization Inventory scores were significantly associated with increased continuous pain intensity, highlighting the role of central sensitization in pain perception. Psychological factors, particularly anxiety and depression, correlated closely with higher pain intensity. Two-point discrimination emerged as a statistically significant predictor of functional ability, suggesting that functional impairment may involve multifaceted factors including neurophysiological measures.

Discussion: The findings underscore the importance of identifying central sensitization and psychological factors to develop targeted, biopsychosocial interventions for lateral elbow tendinopathy. Recognizing the contribution of central mechanisms and emotional health can improve personalized treatment strategies, ultimately enhancing recovery and quality of life. The study emphasizes the necessity for comprehensive assessments that extend beyond pain severity to include psychological evaluations.