Jia-Yi Xia, Xiao-Min Hou, Ke Liu, Min Kong, Ying Ma, Dania Saif, Hua-Dong Ni, Qi-Hong Shen
{"title":"经耳迷走神经刺激用于肩关节镜手术后的术后镇痛：一项双盲、随机、安慰剂对照试验。","authors":"Jia-Yi Xia, Xiao-Min Hou, Ke Liu, Min Kong, Ying Ma, Dania Saif, Hua-Dong Ni, Qi-Hong Shen","doi":"10.1007/s40122-025-00785-9","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Despite growing interest in non-pharmacological analgesia, clinical evidence supporting transauricular vagus nerve stimulation (taVNS) for postoperative pain management following arthroscopic shoulder surgery remains limited. This study aimed to evaluate the efficacy and safety of taVNS in postoperative analgesia after shoulder arthroscopy.</p><p><strong>Methods: </strong>Seventy patients scheduled for arthroscopic shoulder surgery were randomly assigned to two groups on the basis fo computer-generated concealed allocation sequences. The intervention group received taVNS once on the day of surgery and once daily for the following two consecutive days, with each session lasting 2 h. The control group received sham stimulation following an identical schedule. The primary outcome was total sufentanil consumption within 24 h postoperatively.</p><p><strong>Results: </strong>Postoperative sufentanil consumption at 24 and 48 h, resting Numeric Rating Scale (NRS) scores at 4, 6, 12, 24, and 48 h, and the requirement for rescue analgesia were all significantly lower in the taVNS group compared with the sham stimulation group (all P < 0.05). In addition, quality of recovery-15 (QoR-15) scores at 24, 48, and 72 h post surgery were significantly higher in the taVNS group (all P < 0.05). No significant intergroup differences were observed in hemodynamic parameters (all P > 0.05). The incidences of nausea, vomiting, constipation, and gastrointestinal dysmotility were lower in the taVNS group, while other adverse events did not differ significantly between groups.</p><p><strong>Conclusions: </strong>TaVNS demonstrates both safety and efficacy in the management of postoperative pain following shoulder arthroscopy. Its application is associated with a reduction in analgesic requirements and contributes to an improved quality of recovery during the early postoperative period.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov identifier no. ChiCTR2400094087.</p>","PeriodicalId":19908,"journal":{"name":"Pain and Therapy","volume":" ","pages":""},"PeriodicalIF":3.3000,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Transauricular Vagus Nerve Stimulation for Postoperative Analgesia following Arthroscopic Shoulder Surgery: A Double-Blind, Randomized, Placebo-Controlled Trial.\",\"authors\":\"Jia-Yi Xia, Xiao-Min Hou, Ke Liu, Min Kong, Ying Ma, Dania Saif, Hua-Dong Ni, Qi-Hong Shen\",\"doi\":\"10.1007/s40122-025-00785-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Despite growing interest in non-pharmacological analgesia, clinical evidence supporting transauricular vagus nerve stimulation (taVNS) for postoperative pain management following arthroscopic shoulder surgery remains limited. This study aimed to evaluate the efficacy and safety of taVNS in postoperative analgesia after shoulder arthroscopy.</p><p><strong>Methods: </strong>Seventy patients scheduled for arthroscopic shoulder surgery were randomly assigned to two groups on the basis fo computer-generated concealed allocation sequences. The intervention group received taVNS once on the day of surgery and once daily for the following two consecutive days, with each session lasting 2 h. The control group received sham stimulation following an identical schedule. The primary outcome was total sufentanil consumption within 24 h postoperatively.</p><p><strong>Results: </strong>Postoperative sufentanil consumption at 24 and 48 h, resting Numeric Rating Scale (NRS) scores at 4, 6, 12, 24, and 48 h, and the requirement for rescue analgesia were all significantly lower in the taVNS group compared with the sham stimulation group (all P < 0.05). In addition, quality of recovery-15 (QoR-15) scores at 24, 48, and 72 h post surgery were significantly higher in the taVNS group (all P < 0.05). No significant intergroup differences were observed in hemodynamic parameters (all P > 0.05). The incidences of nausea, vomiting, constipation, and gastrointestinal dysmotility were lower in the taVNS group, while other adverse events did not differ significantly between groups.</p><p><strong>Conclusions: </strong>TaVNS demonstrates both safety and efficacy in the management of postoperative pain following shoulder arthroscopy. Its application is associated with a reduction in analgesic requirements and contributes to an improved quality of recovery during the early postoperative period.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov identifier no. ChiCTR2400094087.</p>\",\"PeriodicalId\":19908,\"journal\":{\"name\":\"Pain and Therapy\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2025-10-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pain and Therapy\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s40122-025-00785-9\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pain and Therapy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s40122-025-00785-9","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Transauricular Vagus Nerve Stimulation for Postoperative Analgesia following Arthroscopic Shoulder Surgery: A Double-Blind, Randomized, Placebo-Controlled Trial.
Introduction: Despite growing interest in non-pharmacological analgesia, clinical evidence supporting transauricular vagus nerve stimulation (taVNS) for postoperative pain management following arthroscopic shoulder surgery remains limited. This study aimed to evaluate the efficacy and safety of taVNS in postoperative analgesia after shoulder arthroscopy.
Methods: Seventy patients scheduled for arthroscopic shoulder surgery were randomly assigned to two groups on the basis fo computer-generated concealed allocation sequences. The intervention group received taVNS once on the day of surgery and once daily for the following two consecutive days, with each session lasting 2 h. The control group received sham stimulation following an identical schedule. The primary outcome was total sufentanil consumption within 24 h postoperatively.
Results: Postoperative sufentanil consumption at 24 and 48 h, resting Numeric Rating Scale (NRS) scores at 4, 6, 12, 24, and 48 h, and the requirement for rescue analgesia were all significantly lower in the taVNS group compared with the sham stimulation group (all P < 0.05). In addition, quality of recovery-15 (QoR-15) scores at 24, 48, and 72 h post surgery were significantly higher in the taVNS group (all P < 0.05). No significant intergroup differences were observed in hemodynamic parameters (all P > 0.05). The incidences of nausea, vomiting, constipation, and gastrointestinal dysmotility were lower in the taVNS group, while other adverse events did not differ significantly between groups.
Conclusions: TaVNS demonstrates both safety and efficacy in the management of postoperative pain following shoulder arthroscopy. Its application is associated with a reduction in analgesic requirements and contributes to an improved quality of recovery during the early postoperative period.
期刊介绍：
Pain and Therapy is an international, open access, peer-reviewed, rapid publication journal dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of pain therapies and pain-related devices. Studies relating to diagnosis, pharmacoeconomics, public health, quality of life, and patient care, management, and education are also encouraged.
Areas of focus include, but are not limited to, acute pain, cancer pain, chronic pain, headache and migraine, neuropathic pain, opioids, palliative care and pain ethics, peri- and post-operative pain as well as rheumatic pain and fibromyalgia.
The journal is of interest to a broad audience of pharmaceutical and healthcare professionals and publishes original research, reviews, case reports, trial protocols, short communications such as commentaries and editorials, and letters. The journal is read by a global audience and receives submissions from around the world. Pain and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of all scientifically and ethically sound research.
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