串联硝基还原和酰胺缩合在dna上合成天然产物启发骨架。

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-10-14 DOI:10.1021/acs.orglett.5c03695

Kangyin Pan,Wentao Meng,Ying Yao,Wanting Bi,Guang Yang,Hongtao Xu

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引用次数: 0

摘要

为了促进天然产物元素有效地整合到dna编码文库中，一种强大的，无金属的，dna兼容的硝基还原和原位酰胺缩聚方案已经开发出来。该方法利用dna偶联（杂）芳香硝基亲电试剂和简单氨基酸作为起始材料，能够有效合成结构多样的dna偶联骨架，这些骨架代表生物活性分子或天然产物中常见的核心基序。

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Tandem Nitro Reduction and Amide Condensation for the On-DNA Synthesis of Natural Product-Inspired Skeletons.

To facilitate the efficient incorporation of natural product elements into DNA-encoded libraries, a robust, metal-free, DNA-compatible protocol for nitro reduction and in situ amide condensation has been developed. This methodology utilizes DNA-conjugated (hetero)aromatic nitro electrophiles and simple amino acids as starting materials, enabling the efficient synthesis of structurally diverse DNA-conjugated skeletons that represent core motifs commonly found in bioactive molecules or natural products.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.