Angeliki Ntouli, Georgios Kalaitzakis, John Stratakis, Kostas Perisinakis, Stefanos Kachris, Maria Tolia, Michalis Mazonakis, Thomas G. Maris
{"title":"两种剂量测定系统在脑放疗临床治疗方案中质量保证的比较：二极管阵列和聚合物凝胶剂量测定","authors":"Angeliki Ntouli, Georgios Kalaitzakis, John Stratakis, Kostas Perisinakis, Stefanos Kachris, Maria Tolia, Michalis Mazonakis, Thomas G. Maris","doi":"10.1002/acm2.70272","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Advanced radiotherapy techniques such as single-isocenter volumetric modulated arc therapy (VMAT) and simultaneous integrated boost (SIB-VMAT) require precise quality assurance (QA) due to their complexity and sensitivity to geometric and dosimetric uncertainties, especially for multi-target configurations.</p>\n </section>\n \n <section>\n \n <h3> Purpose</h3>\n \n <p>To evaluate and compare two dosimetric systems—a diode array and a polymer gel dosimeter—for quality assurance in single-isocenter multi-target VMAT and SIB-VMAT plans through 3D gamma index and statistical agreement analysis.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>A diode array system (Delta⁴—Scandidos, Uppsala, Sweden) and a 3D printed phantom (Prime—RTsafe, Athens, Greece) embedded with in-house polymer gel were utilized. The treatment plans for VMAT and SIB-VMAT were created using the Monaco treatment planning system (TPS) and irradiations were performed with the Elekta Infinity linear accelerator with a 6-MV photon beam on both Prime and Delta⁴. Analyses of the irradiated gels were performed using a 1.5T clinical MRI system. Additionally, 3D gamma indexes and Bland-Altman analyses were conducted to evaluate the agreement between relative doses from MRI-derived gel data and diode array's detector measurements.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Diode array system achieved gamma passing rates (GPRs) >99%, while polymer gel showed >95% GPR for both irradiation plans. Bland–Altman analysis indicated minimal bias (mean difference: 0.1%) and narrow limits of agreement (−1.9% to 2.2%), confirming good consistency between the two dosimetric methods for both plans delivered.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Acceptable agreement between the two systems was observed. Both demonstrated complementary capabilities, making both essential tools for ensuring precision in advanced radiotherapy techniques. The polymer gel system offers more detailed insights compared to the diode array method, showing increased sensitivity in challenging cases that involve small targets at greater distances from the isocenter.</p>\n </section>\n </div>","PeriodicalId":14989,"journal":{"name":"Journal of Applied Clinical Medical Physics","volume":"26 10","pages":""},"PeriodicalIF":2.2000,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://aapm.onlinelibrary.wiley.com/doi/epdf/10.1002/acm2.70272","citationCount":"0","resultStr":"{\"title\":\"Comparison of two dosimetric systems for quality assurance in a clinical treatment scenario for brain radiotherapy: Diode array and polymer gel dosimetry\",\"authors\":\"Angeliki Ntouli, Georgios Kalaitzakis, John Stratakis, Kostas Perisinakis, Stefanos Kachris, Maria Tolia, Michalis Mazonakis, Thomas G. Maris\",\"doi\":\"10.1002/acm2.70272\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Advanced radiotherapy techniques such as single-isocenter volumetric modulated arc therapy (VMAT) and simultaneous integrated boost (SIB-VMAT) require precise quality assurance (QA) due to their complexity and sensitivity to geometric and dosimetric uncertainties, especially for multi-target configurations.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Purpose</h3>\\n \\n <p>To evaluate and compare two dosimetric systems—a diode array and a polymer gel dosimeter—for quality assurance in single-isocenter multi-target VMAT and SIB-VMAT plans through 3D gamma index and statistical agreement analysis.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>A diode array system (Delta⁴—Scandidos, Uppsala, Sweden) and a 3D printed phantom (Prime—RTsafe, Athens, Greece) embedded with in-house polymer gel were utilized. The treatment plans for VMAT and SIB-VMAT were created using the Monaco treatment planning system (TPS) and irradiations were performed with the Elekta Infinity linear accelerator with a 6-MV photon beam on both Prime and Delta⁴. Analyses of the irradiated gels were performed using a 1.5T clinical MRI system. Additionally, 3D gamma indexes and Bland-Altman analyses were conducted to evaluate the agreement between relative doses from MRI-derived gel data and diode array's detector measurements.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Diode array system achieved gamma passing rates (GPRs) >99%, while polymer gel showed >95% GPR for both irradiation plans. Bland–Altman analysis indicated minimal bias (mean difference: 0.1%) and narrow limits of agreement (−1.9% to 2.2%), confirming good consistency between the two dosimetric methods for both plans delivered.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusions</h3>\\n \\n <p>Acceptable agreement between the two systems was observed. Both demonstrated complementary capabilities, making both essential tools for ensuring precision in advanced radiotherapy techniques. 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Comparison of two dosimetric systems for quality assurance in a clinical treatment scenario for brain radiotherapy: Diode array and polymer gel dosimetry
Background
Advanced radiotherapy techniques such as single-isocenter volumetric modulated arc therapy (VMAT) and simultaneous integrated boost (SIB-VMAT) require precise quality assurance (QA) due to their complexity and sensitivity to geometric and dosimetric uncertainties, especially for multi-target configurations.
Purpose
To evaluate and compare two dosimetric systems—a diode array and a polymer gel dosimeter—for quality assurance in single-isocenter multi-target VMAT and SIB-VMAT plans through 3D gamma index and statistical agreement analysis.
Methods
A diode array system (Delta⁴—Scandidos, Uppsala, Sweden) and a 3D printed phantom (Prime—RTsafe, Athens, Greece) embedded with in-house polymer gel were utilized. The treatment plans for VMAT and SIB-VMAT were created using the Monaco treatment planning system (TPS) and irradiations were performed with the Elekta Infinity linear accelerator with a 6-MV photon beam on both Prime and Delta⁴. Analyses of the irradiated gels were performed using a 1.5T clinical MRI system. Additionally, 3D gamma indexes and Bland-Altman analyses were conducted to evaluate the agreement between relative doses from MRI-derived gel data and diode array's detector measurements.
Results
Diode array system achieved gamma passing rates (GPRs) >99%, while polymer gel showed >95% GPR for both irradiation plans. Bland–Altman analysis indicated minimal bias (mean difference: 0.1%) and narrow limits of agreement (−1.9% to 2.2%), confirming good consistency between the two dosimetric methods for both plans delivered.
Conclusions
Acceptable agreement between the two systems was observed. Both demonstrated complementary capabilities, making both essential tools for ensuring precision in advanced radiotherapy techniques. The polymer gel system offers more detailed insights compared to the diode array method, showing increased sensitivity in challenging cases that involve small targets at greater distances from the isocenter.
期刊介绍：
Journal of Applied Clinical Medical Physics is an international Open Access publication dedicated to clinical medical physics. JACMP welcomes original contributions dealing with all aspects of medical physics from scientists working in the clinical medical physics around the world. JACMP accepts only online submission.
JACMP will publish:
-Original Contributions: Peer-reviewed, investigations that represent new and significant contributions to the field. Recommended word count: up to 7500.
-Review Articles: Reviews of major areas or sub-areas in the field of clinical medical physics. These articles may be of any length and are peer reviewed.
-Technical Notes: These should be no longer than 3000 words, including key references.
-Letters to the Editor: Comments on papers published in JACMP or on any other matters of interest to clinical medical physics. These should not be more than 1250 (including the literature) and their publication is only based on the decision of the editor, who occasionally asks experts on the merit of the contents.
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-Announcements of Forthcoming Meetings: The Editor may provide notice of forthcoming meetings, course offerings, and other events relevant to clinical medical physics.
-Parallel Opposed Editorial: We welcome topics relevant to clinical practice and medical physics profession. The contents can be controversial debate or opposed aspects of an issue. One author argues for the position and the other against. Each side of the debate contains an opening statement up to 800 words, followed by a rebuttal up to 500 words. Readers interested in participating in this series should contact the moderator with a proposed title and a short description of the topic
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