{"title":"斑秃与高敏感性心肌肌钙蛋白T作为亚临床心肌损伤标志物的关系","authors":"Akam Ramezani, Robabeh Abedini, Ifa Etesami, Shahin Hamzelou, Amirali Barkhordarioon, Safoura Shakoei","doi":"10.1155/dth/6034179","DOIUrl":null,"url":null,"abstract":"<div>\n \n <section>\n \n <h3> Background</h3>\n \n <p>Alopecia areata (AA) is a common autoimmune disorder characterized by nonscarring hair loss, affecting up to 2% of the population. While primarily a dermatological condition, recent studies have explored possible systemic associations, including cardiovascular involvement. Troponins have been a focal point in examining cardiovascular risks in various autoimmune diseases. This study aims to evaluate and compare High-sensitivity cardiac troponin T (hs-cTnT) levels in patients with AA against healthy controls to explore potential cardiovascular risk associations.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>In this cross-sectional study, 45 patients with AA and 45 age- and sex-matched healthy individuals were enrolled. Demographic characteristics of patients, medical history, and lifestyle factors were gathered through questionnaires. Patient blood samples were collected, and hs-cTnT levels were determined using high-sensitivity immunoassays to provide accurate measurements. Statistical analyses were conducted using the SPSS software. Statistical significance was set at <i>p</i> < 0.05.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Both study groups comprised of 26 male and 19 female participants. The mean age of the AA group was 37.33 ± 12.49, and the mean age of the control group was 36.22 ± 12.28. Of the patients with AA, 73.3% had patchy areata, 11.1% had totalis areata, and 15.6% had universalis areata. The mean hs-cTnT levels in the AA group were 4.29 ± 3.54 and 2.87 ± 2.05 for the control group (<i>p</i> value = 0.04). The disease duration exhibited a positive correlation with elevated concentrations of hs-cTnT (<i>p</i> value < 0.001).</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Elevated hs-cTnT levels in patients with AA strengthen the link between AA and cardiovascular diseases. Additional research is needed to clarify the relationship between AA and elevated cardiac markers. Studies with larger sample sizes, long-term follow-ups, and comprehensive cardiac assessments (including laboratory tests and imaging techniques) can provide more definitive evidence to determine the cause of the increased marker levels.</p>\n </section>\n </div>","PeriodicalId":11045,"journal":{"name":"Dermatologic Therapy","volume":"2025 1","pages":""},"PeriodicalIF":3.4000,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/dth/6034179","citationCount":"0","resultStr":"{\"title\":\"Association Between Alopecia Areata and High-Sensitivity Cardiac Troponin T as a Marker of Subclinical Myocardial Injury\",\"authors\":\"Akam Ramezani, Robabeh Abedini, Ifa Etesami, Shahin Hamzelou, Amirali Barkhordarioon, Safoura Shakoei\",\"doi\":\"10.1155/dth/6034179\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Alopecia areata (AA) is a common autoimmune disorder characterized by nonscarring hair loss, affecting up to 2% of the population. While primarily a dermatological condition, recent studies have explored possible systemic associations, including cardiovascular involvement. Troponins have been a focal point in examining cardiovascular risks in various autoimmune diseases. This study aims to evaluate and compare High-sensitivity cardiac troponin T (hs-cTnT) levels in patients with AA against healthy controls to explore potential cardiovascular risk associations.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>In this cross-sectional study, 45 patients with AA and 45 age- and sex-matched healthy individuals were enrolled. Demographic characteristics of patients, medical history, and lifestyle factors were gathered through questionnaires. Patient blood samples were collected, and hs-cTnT levels were determined using high-sensitivity immunoassays to provide accurate measurements. Statistical analyses were conducted using the SPSS software. Statistical significance was set at <i>p</i> < 0.05.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Both study groups comprised of 26 male and 19 female participants. The mean age of the AA group was 37.33 ± 12.49, and the mean age of the control group was 36.22 ± 12.28. Of the patients with AA, 73.3% had patchy areata, 11.1% had totalis areata, and 15.6% had universalis areata. The mean hs-cTnT levels in the AA group were 4.29 ± 3.54 and 2.87 ± 2.05 for the control group (<i>p</i> value = 0.04). The disease duration exhibited a positive correlation with elevated concentrations of hs-cTnT (<i>p</i> value < 0.001).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>Elevated hs-cTnT levels in patients with AA strengthen the link between AA and cardiovascular diseases. Additional research is needed to clarify the relationship between AA and elevated cardiac markers. Studies with larger sample sizes, long-term follow-ups, and comprehensive cardiac assessments (including laboratory tests and imaging techniques) can provide more definitive evidence to determine the cause of the increased marker levels.</p>\\n </section>\\n </div>\",\"PeriodicalId\":11045,\"journal\":{\"name\":\"Dermatologic Therapy\",\"volume\":\"2025 1\",\"pages\":\"\"},\"PeriodicalIF\":3.4000,\"publicationDate\":\"2025-10-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1155/dth/6034179\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Dermatologic Therapy\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1155/dth/6034179\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"DERMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Dermatologic Therapy","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1155/dth/6034179","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DERMATOLOGY","Score":null,"Total":0}
Association Between Alopecia Areata and High-Sensitivity Cardiac Troponin T as a Marker of Subclinical Myocardial Injury
Background
Alopecia areata (AA) is a common autoimmune disorder characterized by nonscarring hair loss, affecting up to 2% of the population. While primarily a dermatological condition, recent studies have explored possible systemic associations, including cardiovascular involvement. Troponins have been a focal point in examining cardiovascular risks in various autoimmune diseases. This study aims to evaluate and compare High-sensitivity cardiac troponin T (hs-cTnT) levels in patients with AA against healthy controls to explore potential cardiovascular risk associations.
Methods
In this cross-sectional study, 45 patients with AA and 45 age- and sex-matched healthy individuals were enrolled. Demographic characteristics of patients, medical history, and lifestyle factors were gathered through questionnaires. Patient blood samples were collected, and hs-cTnT levels were determined using high-sensitivity immunoassays to provide accurate measurements. Statistical analyses were conducted using the SPSS software. Statistical significance was set at p < 0.05.
Results
Both study groups comprised of 26 male and 19 female participants. The mean age of the AA group was 37.33 ± 12.49, and the mean age of the control group was 36.22 ± 12.28. Of the patients with AA, 73.3% had patchy areata, 11.1% had totalis areata, and 15.6% had universalis areata. The mean hs-cTnT levels in the AA group were 4.29 ± 3.54 and 2.87 ± 2.05 for the control group (p value = 0.04). The disease duration exhibited a positive correlation with elevated concentrations of hs-cTnT (p value < 0.001).
Conclusion
Elevated hs-cTnT levels in patients with AA strengthen the link between AA and cardiovascular diseases. Additional research is needed to clarify the relationship between AA and elevated cardiac markers. Studies with larger sample sizes, long-term follow-ups, and comprehensive cardiac assessments (including laboratory tests and imaging techniques) can provide more definitive evidence to determine the cause of the increased marker levels.
期刊介绍：
Dermatologic Therapy has been created to fill an important void in the dermatologic literature: the lack of a readily available source of up-to-date information on the treatment of specific cutaneous diseases and the practical application of specific treatment modalities. Each issue of the journal consists of a series of scholarly review articles written by leaders in dermatology in which they describe, in very specific terms, how they treat particular cutaneous diseases and how they use specific therapeutic agents. The information contained in each issue is so practical and detailed that the reader should be able to directly apply various treatment approaches to daily clinical situations. Because of the specific and practical nature of this publication, Dermatologic Therapy not only serves as a readily available resource for the day-to-day treatment of patients, but also as an evolving therapeutic textbook for the treatment of dermatologic diseases.
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