{"title":"炎症性肠病混合年龄患者焦虑和抑郁的影响因素：一项系统综述和荟萃分析","authors":"Huiling Zhang, Minghua Han, Yapeng He, Lili Wang, Wenya Hou, Jue Guo, Qian Zhao","doi":"10.1080/13548506.2025.2564311","DOIUrl":null,"url":null,"abstract":"<p><p>Recently, the incidence of anxiety and depression in inflammatory bowel disease (IBD) patients has gradually increased. Critically, psychological comorbidities not only compromise quality of life but independently predict adverse IBD outcomes including heightened relapse risk and treatment non-adherence. Therefore, the aim is to conduct a systematic review and meta-analysis on the influencing factors of anxiety and depression in IBD patients and to provide a scientific basis for the effective prevention. We searched PubMed, Embase, PsycINFO, Web of Science and Cochrane Library until 30 January 2024. Included studies were cross-sectional or cohort designs. Quality was assessed using Newcastle-Ottawa Scale and Agency for Healthcare Research and Quality. Data analysis used Stata 16.0 with fixed/random-effects models. Publication bias was assessed via Begg test and funnel plots. Twenty factors (e.g. age, marriage, education) were extracted. From 11, 755 citations, 28 studies (58,064 patients) met criteria. Overall, factors influencing anxiety in IBD patients include gender (OR = 1.85, 95% CI: 1.68-2.04), disease activity (OR = 1.56, 95% CI: 1.16-2.09), IBD-related surgery (OR = 0.64, 95% CI: 0.37-0.79) and non-white ethnicity (OR = 0.74, 95% CI: 0.62-0.88). Factors associated with depression in patients include gender (OR = 1.74, 95% CI: 1.62-1.86), disease activity (OR = 1.89, 95% CI: 1.50-2.39), IBD-related surgery (OR = 1.52, 95% CI: 1.20-1.92), male gender (OR = 1.59, 95% CI: 1.33-1.90), perianal disease (OR = 1.85, 95% CI: 1.35-2.55), higher education (OR = 1.56, 95% CI: 1.22-1.98), steroid use (OR = 2.05, 95% CI: 1.22-3.45), non-white ethnicity (OR = 0.72, 95% CI: 0.62-0.84) and family history (OR = 1.62, 95% CI: 1.33-1.97). Disease activity has a relatively high impact on the emotion of patients with inflammatory bowel disease, and gender differences and side effects of therapeutic drugs also play an auxiliary role. Therefore, early intervention should be carried out for the existence of modifiable risk factors of anxiety and depression in IBD patients.</p>","PeriodicalId":54535,"journal":{"name":"Psychology Health & Medicine","volume":" ","pages":"1-21"},"PeriodicalIF":1.9000,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Influencing factors of anxiety and depression in mixed-age patients with inflammatory bowel disease: a systematic review and meta-analysis.\",\"authors\":\"Huiling Zhang, Minghua Han, Yapeng He, Lili Wang, Wenya Hou, Jue Guo, Qian Zhao\",\"doi\":\"10.1080/13548506.2025.2564311\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Recently, the incidence of anxiety and depression in inflammatory bowel disease (IBD) patients has gradually increased. Critically, psychological comorbidities not only compromise quality of life but independently predict adverse IBD outcomes including heightened relapse risk and treatment non-adherence. Therefore, the aim is to conduct a systematic review and meta-analysis on the influencing factors of anxiety and depression in IBD patients and to provide a scientific basis for the effective prevention. We searched PubMed, Embase, PsycINFO, Web of Science and Cochrane Library until 30 January 2024. Included studies were cross-sectional or cohort designs. Quality was assessed using Newcastle-Ottawa Scale and Agency for Healthcare Research and Quality. Data analysis used Stata 16.0 with fixed/random-effects models. Publication bias was assessed via Begg test and funnel plots. Twenty factors (e.g. age, marriage, education) were extracted. From 11, 755 citations, 28 studies (58,064 patients) met criteria. Overall, factors influencing anxiety in IBD patients include gender (OR = 1.85, 95% CI: 1.68-2.04), disease activity (OR = 1.56, 95% CI: 1.16-2.09), IBD-related surgery (OR = 0.64, 95% CI: 0.37-0.79) and non-white ethnicity (OR = 0.74, 95% CI: 0.62-0.88). Factors associated with depression in patients include gender (OR = 1.74, 95% CI: 1.62-1.86), disease activity (OR = 1.89, 95% CI: 1.50-2.39), IBD-related surgery (OR = 1.52, 95% CI: 1.20-1.92), male gender (OR = 1.59, 95% CI: 1.33-1.90), perianal disease (OR = 1.85, 95% CI: 1.35-2.55), higher education (OR = 1.56, 95% CI: 1.22-1.98), steroid use (OR = 2.05, 95% CI: 1.22-3.45), non-white ethnicity (OR = 0.72, 95% CI: 0.62-0.84) and family history (OR = 1.62, 95% CI: 1.33-1.97). Disease activity has a relatively high impact on the emotion of patients with inflammatory bowel disease, and gender differences and side effects of therapeutic drugs also play an auxiliary role. Therefore, early intervention should be carried out for the existence of modifiable risk factors of anxiety and depression in IBD patients.</p>\",\"PeriodicalId\":54535,\"journal\":{\"name\":\"Psychology Health & Medicine\",\"volume\":\" \",\"pages\":\"1-21\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-10-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Psychology Health & Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/13548506.2025.2564311\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Psychology Health & Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/13548506.2025.2564311","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
Influencing factors of anxiety and depression in mixed-age patients with inflammatory bowel disease: a systematic review and meta-analysis.
Recently, the incidence of anxiety and depression in inflammatory bowel disease (IBD) patients has gradually increased. Critically, psychological comorbidities not only compromise quality of life but independently predict adverse IBD outcomes including heightened relapse risk and treatment non-adherence. Therefore, the aim is to conduct a systematic review and meta-analysis on the influencing factors of anxiety and depression in IBD patients and to provide a scientific basis for the effective prevention. We searched PubMed, Embase, PsycINFO, Web of Science and Cochrane Library until 30 January 2024. Included studies were cross-sectional or cohort designs. Quality was assessed using Newcastle-Ottawa Scale and Agency for Healthcare Research and Quality. Data analysis used Stata 16.0 with fixed/random-effects models. Publication bias was assessed via Begg test and funnel plots. Twenty factors (e.g. age, marriage, education) were extracted. From 11, 755 citations, 28 studies (58,064 patients) met criteria. Overall, factors influencing anxiety in IBD patients include gender (OR = 1.85, 95% CI: 1.68-2.04), disease activity (OR = 1.56, 95% CI: 1.16-2.09), IBD-related surgery (OR = 0.64, 95% CI: 0.37-0.79) and non-white ethnicity (OR = 0.74, 95% CI: 0.62-0.88). Factors associated with depression in patients include gender (OR = 1.74, 95% CI: 1.62-1.86), disease activity (OR = 1.89, 95% CI: 1.50-2.39), IBD-related surgery (OR = 1.52, 95% CI: 1.20-1.92), male gender (OR = 1.59, 95% CI: 1.33-1.90), perianal disease (OR = 1.85, 95% CI: 1.35-2.55), higher education (OR = 1.56, 95% CI: 1.22-1.98), steroid use (OR = 2.05, 95% CI: 1.22-3.45), non-white ethnicity (OR = 0.72, 95% CI: 0.62-0.84) and family history (OR = 1.62, 95% CI: 1.33-1.97). Disease activity has a relatively high impact on the emotion of patients with inflammatory bowel disease, and gender differences and side effects of therapeutic drugs also play an auxiliary role. Therefore, early intervention should be carried out for the existence of modifiable risk factors of anxiety and depression in IBD patients.
期刊介绍：
Psychology, Health & Medicine is a multidisciplinary journal highlighting human factors in health. The journal provides a peer reviewed forum to report on issues of psychology and health in practice. This key publication reaches an international audience, highlighting the variation and similarities within different settings and exploring multiple health and illness issues from theoretical, practical and management perspectives. It provides a critical forum to examine the wide range of applied health and illness issues and how they incorporate psychological knowledge, understanding, theory and intervention. The journal reflects the growing recognition of psychosocial issues as they affect health planning, medical care, disease reaction, intervention, quality of life, adjustment adaptation and management.
For many years theoretical research was very distant from applied understanding. The emerging movement in health psychology, changes in medical care provision and training, and consumer awareness of health issues all contribute to a growing need for applied research. This journal focuses on practical applications of theory, research and experience and provides a bridge between academic knowledge, illness experience, wellbeing and health care practice.
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