{"title":"微极杰弗里流体在病变动脉中的磁控振荡流动:一种基于敏感性分析的非侵入性血栓治疗模型。","authors":"P Vaidehi, J Sasikumar, Mustafa Turkyilmazoglu","doi":"10.1016/j.compbiomed.2025.111133","DOIUrl":null,"url":null,"abstract":"<p><p>The study addresses the complex hemodynamics of diseased arteries by incorporating micropolar and Jeffrey fluid characteristics under magnetic influence, which is significant for improving non-invasive diagnostic and therapeutic strategies. The primary aim is to analyze the effect of vortex viscosity, spin gradient viscosity, micro-inertia, fluid elasticity and magnetic fields on oscillatory blood flow, microrotation and heat transfer in a stenosed arterial segment. The governing equations for velocity, microrotation and temperature are non-dimensionalized and solved using the Crank-Nicolson finite difference method, with additional sensitivity and uncertainty analyses performed via orthogonal array techniques and Monte Carlo simulations. Results reveal that magnetic fields reduce flow velocity and microrotation due to Lorentz force damping, while fluid elasticity enhances them and that heat transfer is most sensitive to the Eckert and Peclet numbers, with vortex and spin gradient viscosities having the strongest impact on couple stress. These findings provide a robust computational framework for predicting flow and thermal behaviors in magnetically assisted treatments, supporting targeted clinical applications such as magnetic therapy, vascular hyperthermia and localized drug delivery.</p>","PeriodicalId":10578,"journal":{"name":"Computers in biology and medicine","volume":"198 Pt A","pages":"111133"},"PeriodicalIF":6.3000,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Magnetically controlled oscillatory flow of micropolar-Jeffrey fluid in a diseased artery: A sensitivity analysis-based model for non-invasive thrombosis treatment.\",\"authors\":\"P Vaidehi, J Sasikumar, Mustafa Turkyilmazoglu\",\"doi\":\"10.1016/j.compbiomed.2025.111133\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The study addresses the complex hemodynamics of diseased arteries by incorporating micropolar and Jeffrey fluid characteristics under magnetic influence, which is significant for improving non-invasive diagnostic and therapeutic strategies. The primary aim is to analyze the effect of vortex viscosity, spin gradient viscosity, micro-inertia, fluid elasticity and magnetic fields on oscillatory blood flow, microrotation and heat transfer in a stenosed arterial segment. The governing equations for velocity, microrotation and temperature are non-dimensionalized and solved using the Crank-Nicolson finite difference method, with additional sensitivity and uncertainty analyses performed via orthogonal array techniques and Monte Carlo simulations. Results reveal that magnetic fields reduce flow velocity and microrotation due to Lorentz force damping, while fluid elasticity enhances them and that heat transfer is most sensitive to the Eckert and Peclet numbers, with vortex and spin gradient viscosities having the strongest impact on couple stress. These findings provide a robust computational framework for predicting flow and thermal behaviors in magnetically assisted treatments, supporting targeted clinical applications such as magnetic therapy, vascular hyperthermia and localized drug delivery.</p>\",\"PeriodicalId\":10578,\"journal\":{\"name\":\"Computers in biology and medicine\",\"volume\":\"198 Pt A\",\"pages\":\"111133\"},\"PeriodicalIF\":6.3000,\"publicationDate\":\"2025-10-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Computers in biology and medicine\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1016/j.compbiomed.2025.111133\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Computers in biology and medicine","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1016/j.compbiomed.2025.111133","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOLOGY","Score":null,"Total":0}
Magnetically controlled oscillatory flow of micropolar-Jeffrey fluid in a diseased artery: A sensitivity analysis-based model for non-invasive thrombosis treatment.
The study addresses the complex hemodynamics of diseased arteries by incorporating micropolar and Jeffrey fluid characteristics under magnetic influence, which is significant for improving non-invasive diagnostic and therapeutic strategies. The primary aim is to analyze the effect of vortex viscosity, spin gradient viscosity, micro-inertia, fluid elasticity and magnetic fields on oscillatory blood flow, microrotation and heat transfer in a stenosed arterial segment. The governing equations for velocity, microrotation and temperature are non-dimensionalized and solved using the Crank-Nicolson finite difference method, with additional sensitivity and uncertainty analyses performed via orthogonal array techniques and Monte Carlo simulations. Results reveal that magnetic fields reduce flow velocity and microrotation due to Lorentz force damping, while fluid elasticity enhances them and that heat transfer is most sensitive to the Eckert and Peclet numbers, with vortex and spin gradient viscosities having the strongest impact on couple stress. These findings provide a robust computational framework for predicting flow and thermal behaviors in magnetically assisted treatments, supporting targeted clinical applications such as magnetic therapy, vascular hyperthermia and localized drug delivery.
期刊介绍:
Computers in Biology and Medicine is an international forum for sharing groundbreaking advancements in the use of computers in bioscience and medicine. This journal serves as a medium for communicating essential research, instruction, ideas, and information regarding the rapidly evolving field of computer applications in these domains. By encouraging the exchange of knowledge, we aim to facilitate progress and innovation in the utilization of computers in biology and medicine.