儿童心脏移植免疫风险分层的联合分子错配评分。

IF 2.5 4区医学 Q3 TRANSPLANTATION

Current Opinion in Organ Transplantation Pub Date : 2025-12-01 Epub Date: 2025-10-03 DOI:10.1097/MOT.0000000000001255

Mitchell A Ellison, Qingyong Xu, Adriana Zeevi

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引用次数: 0

摘要

综述目的：本文将回顾HLA分子不匹配算法在预测儿童心脏移植受者重新发生DSA和排斥反应风险中的应用。在这里，我们将重点关注使用hlammatchmaker或HLA-EMMA与PIRCHE-II配对的组合算法方法获得的结果。最近的发现：联合算法方法最近被用于评估儿童器官移植临床试验中儿童心脏移植队列的从头DSA和排斥反应的风险。这种分析HLA分子错配数据的方法比任何单独的算法都能更细致地评估从头DSA和排斥风险。HLA分子错配方法的进展可能使个性化免疫抑制管理成为可能，从而改善儿童心脏移植受者的预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Combined molecular mismatch scores for immunologic risk stratification in pediatric heart transplantation.

Purpose of review: This article will review the use of HLA molecular mismatch algorithms to predict the risk of de-novo DSA and rejection in pediatric heart transplant recipients. Here, we will focus on results obtained using the combined algorithm approach pairing HLAMatchmaker or HLA-EMMA with PIRCHE-II.

Recent findings: The combined algorithm approach was recently used to assess risk of de-novo DSA and rejection in a pediatric heart transplant cohort from Clinical Trials in Organ Transplant in Children 04/09. This approach to analyzing HLA molecular mismatch data allowed for a more granular assessment of de-novo DSA and rejection risk than any individual algorithm.

Summary: Advances in HLA molecular mismatch methods may enable personalized immunosuppression management that improves outcomes of pediatric heart transplant recipients.

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来源期刊

Current Opinion in Organ Transplantation 医学-移植

CiteScore

4.10

自引率

4.50%

发文量

124

审稿时长

6-12 weeks

期刊介绍： Current Opinion in Organ Transplantation is an indispensable resource featuring key, up-to-date and important advances in the field from around the world. Led by renowned guest editors for each section, every bimonthly issue of Current Opinion in Organ Transplantation delivers a fresh insight into topics such as stem cell transplantation, immunosuppression, tolerance induction and organ preservation and procurement. With 18 sections in total, the journal provides a convenient and thorough review of the field and will be of interest to researchers, surgeons and other healthcare professionals alike.