拟南芥叶绿体功能缺失突变体显示白化表型，表明仅具有叶绿体功能。

IF 3.7 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochimica et biophysica acta. Molecular cell research Pub Date : 2025-10-09 DOI:10.1016/j.bbamcr.2025.120068

Sarah Jessup , Ruchira Sepali Mallawa Arachchi , Chris Carrie

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引用次数: 0

摘要

一种功能性线粒体Tat （mtTat）途径已在植物中得到证实，但TatA亚基的存在或需要仍未得到解答。两种相互竞争的假设表明，要么植物线粒体含有不寻常的Tat途径而没有TatA贡献，要么叶绿体TatA （cpTatA）双重靶向叶绿体和线粒体。拟南芥cptata功能丧失突变体表现出与功能失调的叶绿体Tat途径一致的白化表型，对线粒体复合体III的生物发生没有定量影响，重申了cptata在叶绿体中的特异性作用。虽然这些发现否定了双靶向假说，但植物线粒体Tat通路的作用和组成尚未得到充分阐明。

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Arabidopsis thaliana loss-of-function chloroplast tata mutants display an albino phenotype indicating a chloroplast-only function

A functional mitochondrial Tat (mtTat) pathway has been confirmed in plants, but the existence or need for a TatA subunit remains unanswered.

Two competing hypotheses have suggested that either plant mitochondria contain an unusual Tat pathway with no TatA contribution, or the chloroplast TatA (cpTatA) is dually targeted to chloroplasts and mitochondria.

Arabidopsis thaliana cptata loss-of-function mutants display an albino phenotype consistent with a dysfunctional chloroplast Tat pathway with no quantitative impact on mitochondrial complex III biogenesis, reiterating a chloroplast-specific role of cpTatA.

While these findings reject the dual-targeting hypothesis, the roles and components of the plant mitochondrial Tat pathway are yet to be fully elucidated.

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来源期刊

Biochimica et biophysica acta. Molecular cell research 生物-生化与分子生物学

CiteScore

10.00

自引率

2.00%

发文量

151

审稿时长

44 days

期刊介绍： BBA Molecular Cell Research focuses on understanding the mechanisms of cellular processes at the molecular level. These include aspects of cellular signaling, signal transduction, cell cycle, apoptosis, intracellular trafficking, secretory and endocytic pathways, biogenesis of cell organelles, cytoskeletal structures, cellular interactions, cell/tissue differentiation and cellular enzymology. Also included are studies at the interface between Cell Biology and Biophysics which apply for example novel imaging methods for characterizing cellular processes.