间歇性禁食加上早期限时饮食和卡路里限制对2型糖尿病风险成人全身和脂肪组织炎症标志物的影响：一项探索性亚研究

IF 2.5 3区医学 Q3 NUTRITION & DIETETICS

Journal of Human Nutrition and Dietetics Pub Date : 2025-10-08 DOI:10.1111/jhn.70137

Laurent Turner, Lijun Zhao, Kai Liu, Xiao Tong Teong, Gary Wittert, Amy T. Hutchison, Leonie K. Heilbronn

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引用次数: 0

摘要

背景：间歇性禁食（IF）和卡路里限制（CR）可以减少炎症，尽管尚不清楚哪一种对有2型糖尿病风险的成年人更有效。目的：本探索性亚研究比较了IF +早期限时饮食（iTRE）或CR与标准护理（SC）对全身和脂肪组织炎症标志物的影响。方法：将成人（N = 209, 34.8±4.7 kg/m2）随机分为3组（2:2:1）：iTRE（每周3天，0800 ~ 1200之间的30%能量需求）；CR（30%能量限制）；或SC 6个月。在基线和第6个月，体重减轻高于（CR: N = 32, iTRE: N = 35）或低于中位数（SC: N = 18）的亚组测量体重和血浆c反应蛋白（CRP）、肿瘤坏死因子α (TNF-α)、白细胞介素6 （IL-6）和干扰素-α (IFN -α)。采用qPCR检测脂肪组织中炎症基因的表达。结果：与SC相比，iTRE和CR组的体重减轻更大，而TNF-α和CRP水平在第6个月下降（CRP: -1.36±0.47 mg/dL, p）。结论：减肥干预模式对体重减轻中位数以上的参与者的炎症标志物没有差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Impact of Achieved Weight Loss by Intermittent Fasting Plus Early Time-Restricted Eating and Calorie Restriction on Systemic and Adipose Tissue Markers of Inflammation in Adults at Risk of Type 2 Diabetes: An Exploratory Sub-Study

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Background

Intermittent fasting (IF) and calorie restriction (CR) may reduce inflammation, though it is unclear which is more effective in adults at risk of type 2 diabetes.

Objective

This exploratory sub-study compared the effects of achieved weight loss by IF plus early time-restricted eating (iTRE) or CR versus standard care (SC) on systemic and adipose tissue markers of inflammation.

Methods

Adults (N = 209, 34.8 ± 4.7 kg/m²) were randomised into three groups (2:2:1): iTRE (30% energy requirements between 0800 and 1200 on 3 days/week); CR (30% energy restriction); or SC for 6 months. Body weight and plasma C-reactive protein (CRP), tumour necrosis factor α (TNF-α), interleukin-6 (IL-6) and interferon-ɣ (IFNɣ) were measured at baseline and month 6 in a subset with weight loss above (CR: N = 32, iTRE: N = 35) or below median (SC: N = 18). The expression of inflammatory genes in adipose tissue was measured using qPCR.

Results

Weight loss was greater in iTRE and CR versus SC. While TNF-α and CRP levels decreased at month 6 (CRP: −1.36 ± 0.47 mg/dL, p < 0.001; TNF-α: −0.082 ± 0.03 pg/mL, p = 0.025), there were no between group effects. In adipose tissue, no differences in inflammatory genes were detected.

Conclusions

The mode of weight loss intervention did not differentially impact inflammatory markers in participants with weight loss above median.

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来源期刊

Journal of Human Nutrition and Dietetics 医学-营养学

CiteScore

5.30

自引率

15.20%

发文量

133

审稿时长

6-12 weeks

期刊介绍： Journal of Human Nutrition and Dietetics is an international peer-reviewed journal publishing papers in applied nutrition and dietetics. Papers are therefore welcomed on: - Clinical nutrition and the practice of therapeutic dietetics - Clinical and professional guidelines - Public health nutrition and nutritional epidemiology - Dietary surveys and dietary assessment methodology - Health promotion and intervention studies and their effectiveness - Obesity, weight control and body composition - Research on psychological determinants of healthy and unhealthy eating behaviour. Focus can for example be on attitudes, brain correlates of food reward processing, social influences, impulsivity, cognitive control, cognitive processes, dieting, psychological treatments. - Appetite, Food intake and nutritional status - Nutrigenomics and molecular nutrition - The journal does not publish animal research The journal is published in an online-only format. No printed issue of this title will be produced but authors will still be able to order offprints of their own articles.