酿酒酵母菌，假丝酵母菌和新型隐球菌β-CAs。

Q3 Biochemistry, Genetics and Molecular Biology

Enzymes Pub Date : 2025-01-01 Epub Date: 2025-07-19 DOI:10.1016/bs.enz.2025.07.001

Anna Di Fiore, Martina Buonanno, Davide Esposito, Katia D'Ambrosio, Emma Langella, Giuseppina De Simone, Vincenzo Alterio, Simona Maria Monti

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引用次数: 0

摘要

碳酸酐酶是一种普遍存在的金属酶，它催化二氧化碳水合成碳酸氢盐和质子。来自真菌的β-碳酸酐酶，如酿酒酵母、念珠菌和新型隐球菌，已被广泛研究作为抗真菌治疗的潜在靶点。在本章中，我们全面概述了它们的性质，重点介绍了它们作为CO₂感应酶的作用。我们综述了其功能、生化、结构和动力学特征，总结了抑制和激活的研究，并回顾了体外实验。综上所述，这些数据强调真菌β -碳酸酐酶是开发新的抗真菌策略的有希望的潜在靶点。

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Saccharomyces cerevesiae, Candida spp. and Cryptococcus neoformans β-CAs.

Carbonic anhydrases are ubiquitous metalloenzymes which catalyze the CO₂ hydration to bicarbonate and proton. β-Carbonic Anhydrases from fungi, such as Saccharomyces cerevisiae, Candida spp. and Cryptococcus neoformans, have been widely investigated as potential targets for antifungal therapies. In this chapter, we provide a comprehensive overview on their properties highlighting their role as CO₂-sensing enzymes. We survey functional, biochemical, structural, and kinetic features, summarize inhibition and activation studies, and review in vitro experiments. Taken together, these data underscore fungal β‑carbonic anhydrases as promising potential targets for the development of new antifungal strategies.

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来源期刊

Enzymes Biochemistry, Genetics and Molecular Biology-Biotechnology

CiteScore

4.30

自引率

0.00%

发文量