{"title":"影响范围：从披萨到蛋白酶的完美切片。","authors":"Nicholas J Lennemann","doi":"10.1128/msphere.00556-25","DOIUrl":null,"url":null,"abstract":"<p><p>Nick Lennemann studies the intracellular interactions of viral and host proteins. In this mSphere of Influence article, he discusses his employment history and the mentors that promoted his training and transition to an independent research program focused on proteolytic determinants of virus infection. He highlights how \"A novel interaction between dengue virus nonstructural protein 1 and the NS4A-2K-4B precursor is required for viral RNA replication but not for formation of the membranous replication organelle\" by A. Płaszczyca, P. Scaturro, C. J. Neufeldt, M. Cortese, et al. (PLoS Pathog 15:e1007736, 2019, https://doi.org/10.1371/journal.ppat.1007736) and \"Species-specific disruption of STING-dependent antiviral cellular defenses by the Zika virus NS2B3 protease\" by Q. Ding, J. M. Gaska, F. Douam, L. Wei, et al. (Proc Natl Acad Sci USA 115: E6310-E6318, 2018, https://doi.org/10.1073/pnas.1803406115) demonstrate the importance of viral protease activity for the establishment of a productive intracellular environment for infection.</p>","PeriodicalId":19052,"journal":{"name":"mSphere","volume":" ","pages":"e0055625"},"PeriodicalIF":3.1000,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"mSphere of Influence: The perfect slice-from pizza to proteases.\",\"authors\":\"Nicholas J Lennemann\",\"doi\":\"10.1128/msphere.00556-25\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Nick Lennemann studies the intracellular interactions of viral and host proteins. In this mSphere of Influence article, he discusses his employment history and the mentors that promoted his training and transition to an independent research program focused on proteolytic determinants of virus infection. He highlights how \\\"A novel interaction between dengue virus nonstructural protein 1 and the NS4A-2K-4B precursor is required for viral RNA replication but not for formation of the membranous replication organelle\\\" by A. Płaszczyca, P. Scaturro, C. J. Neufeldt, M. Cortese, et al. (PLoS Pathog 15:e1007736, 2019, https://doi.org/10.1371/journal.ppat.1007736) and \\\"Species-specific disruption of STING-dependent antiviral cellular defenses by the Zika virus NS2B3 protease\\\" by Q. Ding, J. M. Gaska, F. Douam, L. Wei, et al. (Proc Natl Acad Sci USA 115: E6310-E6318, 2018, https://doi.org/10.1073/pnas.1803406115) demonstrate the importance of viral protease activity for the establishment of a productive intracellular environment for infection.</p>\",\"PeriodicalId\":19052,\"journal\":{\"name\":\"mSphere\",\"volume\":\" \",\"pages\":\"e0055625\"},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2025-10-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"mSphere\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1128/msphere.00556-25\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"mSphere","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1128/msphere.00556-25","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
Nick Lennemann研究病毒和宿主蛋白的细胞内相互作用。在这篇mSphere of Influence文章中，他讨论了他的工作经历和导师，这些导师促进了他的培训，并使他过渡到一个专注于病毒感染的蛋白水解决定因素的独立研究项目。他强调了A. Płaszczyca， P. Scaturro， C. J. Neufeldt， M. Cortese等人（PLoS Pathog 15:e1007736, 2019, https://doi.org/10.1371/journal.ppat.1007736）“登革热病毒非结构蛋白1与NS4A-2K-4B前体之间的一种新的相互作用是病毒RNA复制所必需的，但不是膜复制细胞器形成所必需的”，以及Q. Ding， J. M. Gaska的“Zika病毒NS2B3蛋白酶对sting依赖性抗病毒细胞防御的物种特异性破坏”。F. Douam， L. Wei等（Proc Natl Acad Sci USA 115: E6310-E6318, 2018, https://doi.org/10.1073/pnas.1803406115）证明了病毒蛋白酶活性对建立细胞内感染环境的重要性。
mSphere of Influence: The perfect slice-from pizza to proteases.
Nick Lennemann studies the intracellular interactions of viral and host proteins. In this mSphere of Influence article, he discusses his employment history and the mentors that promoted his training and transition to an independent research program focused on proteolytic determinants of virus infection. He highlights how "A novel interaction between dengue virus nonstructural protein 1 and the NS4A-2K-4B precursor is required for viral RNA replication but not for formation of the membranous replication organelle" by A. Płaszczyca, P. Scaturro, C. J. Neufeldt, M. Cortese, et al. (PLoS Pathog 15:e1007736, 2019, https://doi.org/10.1371/journal.ppat.1007736) and "Species-specific disruption of STING-dependent antiviral cellular defenses by the Zika virus NS2B3 protease" by Q. Ding, J. M. Gaska, F. Douam, L. Wei, et al. (Proc Natl Acad Sci USA 115: E6310-E6318, 2018, https://doi.org/10.1073/pnas.1803406115) demonstrate the importance of viral protease activity for the establishment of a productive intracellular environment for infection.
期刊介绍：
mSphere™ is a multi-disciplinary open-access journal that will focus on rapid publication of fundamental contributions to our understanding of microbiology. Its scope will reflect the immense range of fields within the microbial sciences, creating new opportunities for researchers to share findings that are transforming our understanding of human health and disease, ecosystems, neuroscience, agriculture, energy production, climate change, evolution, biogeochemical cycling, and food and drug production. Submissions will be encouraged of all high-quality work that makes fundamental contributions to our understanding of microbiology. mSphere™ will provide streamlined decisions, while carrying on ASM''s tradition for rigorous peer review.
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