目前专家对神经性角膜疼痛管理方法的国际调查。

IF 3.2 3区医学 Q2 OPHTHALMOLOGY

Ophthalmology and Therapy Pub Date : 2025-10-08 DOI:10.1007/s40123-025-01242-8

Samy El Omda, Nikolaos Tzoumas, Margarita Calonge, Francisco Figueiredo

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引用次数: 0

摘要

神经性角膜疼痛（NCP）是一种具有挑战性的疾病，对其诊断和治疗的共识有限。本研究旨在收集全球角膜专家对NCP的病因、调查方法和管理策略的见解。方法：向152名受邀的国际角膜专家发送一份包含人口统计学、病因、调查、治疗和多学科参与的32个问题的调查；51人（34%）回应。我们探索了描述性统计，并检查了应答者的特征如何影响他们的答案。结果：报告最多的NCP病因是慢性眼表疾病（n = 41; 41%）和术后因素（n = 34; 34%）。最常见的检查是麻醉激发试验、Schirmer试验和角膜感觉测量。37% （n = 19）的专家常规使用体内共聚焦显微镜（IVCM）， 69% （n = 29）的专家表示异常结果影响了他们的治疗。69% （n = 35）使用眼表和疼痛问卷，其中眼表疾病指数最受欢迎（n = 25; 31%）。常见的治疗方法包括人工泪液（n = 48; 94%）、血清/血浆来源泪液（n = 41; 80%）、外用皮质类固醇（n = 34; 67%）和外用环孢素（n = 30; 59%）。只有38% （n = 19）的患者对独立开全身药物治疗处方感到放心。47% （n = 24）的患者采用多学科方法，其中两个最常见的专科是疼痛管理（n = 30, 37%）和神经病学（n = 26, 32%）。结论：本调查从角膜专家的角度对NCP的病因、调查和管理提供了有价值的全球见解。这些发现支持进一步的研究和指导方针的发展，以解决这一具有挑战性的条件。

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International Survey of Current Approaches to the Management of Neuropathic Corneal Pain by Experts.

Introduction: Neuropathic corneal pain (NCP) is a challenging condition with limited consensus on its diagnosis and management. This study aimed to gather global insights from corneal specialists on the causes, investigative approaches, and management strategies for NCP.

Methods: A 32-question survey covering demographic, causes, investigations, treatments, and multidisciplinary engagement was sent to 152 invited international corneal specialists; 51 (34%) responded. We explored descriptive statistics and examined how responder characteristics influenced their answers.

Results: The most reported causes of NCP were chronic ocular surface disease (n = 41; 41%) and post-surgical factors (n = 34; 34%). The most common investigations, routinely performed by respondents, were the anesthetic challenge test, Schirmer's test, and corneal esthesiometry. In vivo confocal microscopy (IVCM) was routinely used by 37% (n = 19), with 69% (n = 29) of specialists stating that an abnormal result influenced their management. Ocular surface and pain questionnaires were used by 69% (n = 35), with the Ocular Surface Disease Index being the most popular (n = 25; 31%). Common treatments included artificial tears (n = 48; 94%), serum/plasma-derived tears (n = 41; 80%), topical corticosteroids (n = 34; 67%), and topical cyclosporin (n = 30; 59%). Only 38% (n = 19) felt comfortable independently prescribing systemic pharmacotherapy. A multidisciplinary approach was adopted by 47% (n = 24), with the two most common specialties involved being pain management (n = 30; 37%) and neurology (n = 26, 32%).

Conclusions: This survey provides valuable global insights into the causes, investigations, and management of NCP from the perspective of corneal specialists. These findings support further research and the development of guidelines to address this challenging condition.

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来源期刊

Ophthalmology and Therapy OPHTHALMOLOGY-

CiteScore

4.20

自引率

3.00%

发文量

157

审稿时长

6 weeks

期刊介绍： Aims and Scope Ophthalmology and Therapy is an international, open access, peer-reviewed (single-blind), and rapid publication journal. The scope of the journal is broad and will consider all scientifically sound research from preclinical, clinical (all phases), observational, real-world, and health outcomes research around the use of ophthalmological therapies, devices, and surgical techniques. The journal is of interest to a broad audience of pharmaceutical and healthcare professionals and publishes original research, reviews, case reports/series, trial protocols and short communications such as commentaries and editorials. Ophthalmology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of quality research, which may be considered of insufficient interest by other journals. Rapid Publication The journal’s publication timelines aim for a rapid peer review of 2 weeks. If an article is accepted it will be published 3–4 weeks from acceptance. The rapid timelines are achieved through the combination of a dedicated in-house editorial team, who manage article workflow, and an extensive Editorial and Advisory Board who assist with peer review. This allows the journal to support the rapid dissemination of research, whilst still providing robust peer review. Combined with the journal’s open access model this allows for the rapid, efficient communication of the latest research and reviews, fostering the advancement of ophthalmic therapies. Open Access All articles published by Ophthalmology and Therapy are open access. 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