Narjes Ahmadian, Mark Gosselink, Sigrid Otto, Dimitri Welting, Kiki Tesselaar, Tom Snijders, Pieter van Eijsden, Jeanine Prompers, Dennis Klomp, Evita Wiegers
{"title":"胶质母细胞瘤7T时的动态氘代谢成像。","authors":"Narjes Ahmadian, Mark Gosselink, Sigrid Otto, Dimitri Welting, Kiki Tesselaar, Tom Snijders, Pieter van Eijsden, Jeanine Prompers, Dennis Klomp, Evita Wiegers","doi":"10.1007/s10334-025-01299-3","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>This study investigates the dynamic metabolic characteristics of glioblastoma (GBM) using Deuterium Metabolic Imaging (DMI) at 7 T, aiming to dynamically characterize the Warburg effect in vivo.</p><p><strong>Material and methods: </strong>Five newly diagnosed GBM patients underwent dynamic DMI prior to any treatment. 3D <sup>2</sup>H free-induction-decay (FID)-Magnetic resonance spectroscopy imaging (MRSI) measurements (11:44 min per scan) were performed at 7 T during ~ 100 min following [6,6'-<sup>2</sup>H<sub>2</sub>]glucose consumption. Venous plasma glucose and plasma <sup>2</sup>H-Glc atom percent enrichment (APE) levels were measured during the scan. Brain <sup>2</sup>H-glucose (<sup>2</sup>H-Glc),<sup>2</sup>H-Glutamate/Glutamine (<sup>2</sup>H-Glx), <sup>2</sup>H-Lactate (<sup>2</sup>H-Lac), <sup>2</sup>H-Lac/<sup>2</sup>H-Glx were analyzed with a two-level (time and tissue type) Linear Mixed Model.</p><p><strong>Results: </strong>Brain <sup>2</sup>H-Glc levels were similar across tissue types. <sup>2</sup>H-Glx was significantly lower in tumors compared to normal appearing brain tissue (NABT) (p < 0.01). <sup>2</sup>H-Lac was significantly higher in tumors compared to NABT (P < 0.01). The <sup>2</sup>H-Lac/<sup>2</sup>H-Glx ratio provided tumor-specific contrast, starting 40-50 min post [6,6'-<sup>2</sup>H<sub>2</sub>]glucose consumption. Venous plasma glucose and <sup>2</sup>H-Glc APE increased within 50 min and venous <sup>2</sup>H-Glc APE stabilized at ~ 60%.</p><p><strong>Discussion: </strong>Dynamic DMI at 7 T reveals metabolic alterations in GBM, particularly through the <sup>2</sup>H-Lac/<sup>2</sup>H-Glx ratio. This contrast was primarily driven by decreased <sup>2</sup>H-Glx rather than profoundly increased <sup>2</sup>H-Lac. These findings support the utility of DMI in assessing metabolic reprogramming in brain tumors.</p>","PeriodicalId":18067,"journal":{"name":"Magnetic Resonance Materials in Physics, Biology and Medicine","volume":" ","pages":""},"PeriodicalIF":2.5000,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Dynamic deuterium metabolic imaging in glioblastoma at 7T.\",\"authors\":\"Narjes Ahmadian, Mark Gosselink, Sigrid Otto, Dimitri Welting, Kiki Tesselaar, Tom Snijders, Pieter van Eijsden, Jeanine Prompers, Dennis Klomp, Evita Wiegers\",\"doi\":\"10.1007/s10334-025-01299-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>This study investigates the dynamic metabolic characteristics of glioblastoma (GBM) using Deuterium Metabolic Imaging (DMI) at 7 T, aiming to dynamically characterize the Warburg effect in vivo.</p><p><strong>Material and methods: </strong>Five newly diagnosed GBM patients underwent dynamic DMI prior to any treatment. 3D <sup>2</sup>H free-induction-decay (FID)-Magnetic resonance spectroscopy imaging (MRSI) measurements (11:44 min per scan) were performed at 7 T during ~ 100 min following [6,6'-<sup>2</sup>H<sub>2</sub>]glucose consumption. Venous plasma glucose and plasma <sup>2</sup>H-Glc atom percent enrichment (APE) levels were measured during the scan. Brain <sup>2</sup>H-glucose (<sup>2</sup>H-Glc),<sup>2</sup>H-Glutamate/Glutamine (<sup>2</sup>H-Glx), <sup>2</sup>H-Lactate (<sup>2</sup>H-Lac), <sup>2</sup>H-Lac/<sup>2</sup>H-Glx were analyzed with a two-level (time and tissue type) Linear Mixed Model.</p><p><strong>Results: </strong>Brain <sup>2</sup>H-Glc levels were similar across tissue types. <sup>2</sup>H-Glx was significantly lower in tumors compared to normal appearing brain tissue (NABT) (p < 0.01). <sup>2</sup>H-Lac was significantly higher in tumors compared to NABT (P < 0.01). The <sup>2</sup>H-Lac/<sup>2</sup>H-Glx ratio provided tumor-specific contrast, starting 40-50 min post [6,6'-<sup>2</sup>H<sub>2</sub>]glucose consumption. Venous plasma glucose and <sup>2</sup>H-Glc APE increased within 50 min and venous <sup>2</sup>H-Glc APE stabilized at ~ 60%.</p><p><strong>Discussion: </strong>Dynamic DMI at 7 T reveals metabolic alterations in GBM, particularly through the <sup>2</sup>H-Lac/<sup>2</sup>H-Glx ratio. This contrast was primarily driven by decreased <sup>2</sup>H-Glx rather than profoundly increased <sup>2</sup>H-Lac. These findings support the utility of DMI in assessing metabolic reprogramming in brain tumors.</p>\",\"PeriodicalId\":18067,\"journal\":{\"name\":\"Magnetic Resonance Materials in Physics, Biology and Medicine\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2025-10-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Magnetic Resonance Materials in Physics, Biology and Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s10334-025-01299-3\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Magnetic Resonance Materials in Physics, Biology and Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10334-025-01299-3","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
Dynamic deuterium metabolic imaging in glioblastoma at 7T.
Objective: This study investigates the dynamic metabolic characteristics of glioblastoma (GBM) using Deuterium Metabolic Imaging (DMI) at 7 T, aiming to dynamically characterize the Warburg effect in vivo.
Material and methods: Five newly diagnosed GBM patients underwent dynamic DMI prior to any treatment. 3D 2H free-induction-decay (FID)-Magnetic resonance spectroscopy imaging (MRSI) measurements (11:44 min per scan) were performed at 7 T during ~ 100 min following [6,6'-2H2]glucose consumption. Venous plasma glucose and plasma 2H-Glc atom percent enrichment (APE) levels were measured during the scan. Brain 2H-glucose (2H-Glc),2H-Glutamate/Glutamine (2H-Glx), 2H-Lactate (2H-Lac), 2H-Lac/2H-Glx were analyzed with a two-level (time and tissue type) Linear Mixed Model.
Results: Brain 2H-Glc levels were similar across tissue types. 2H-Glx was significantly lower in tumors compared to normal appearing brain tissue (NABT) (p < 0.01). 2H-Lac was significantly higher in tumors compared to NABT (P < 0.01). The 2H-Lac/2H-Glx ratio provided tumor-specific contrast, starting 40-50 min post [6,6'-2H2]glucose consumption. Venous plasma glucose and 2H-Glc APE increased within 50 min and venous 2H-Glc APE stabilized at ~ 60%.
Discussion: Dynamic DMI at 7 T reveals metabolic alterations in GBM, particularly through the 2H-Lac/2H-Glx ratio. This contrast was primarily driven by decreased 2H-Glx rather than profoundly increased 2H-Lac. These findings support the utility of DMI in assessing metabolic reprogramming in brain tumors.
期刊介绍：
MAGMA is a multidisciplinary international journal devoted to the publication of articles on all aspects of magnetic resonance techniques and their applications in medicine and biology. MAGMA currently publishes research papers, reviews, letters to the editor, and commentaries, six times a year. The subject areas covered by MAGMA include:
advances in materials, hardware and software in magnetic resonance technology,
new developments and results in research and practical applications of magnetic resonance imaging and spectroscopy related to biology and medicine,
study of animal models and intact cells using magnetic resonance,
reports of clinical trials on humans and clinical validation of magnetic resonance protocols.
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