{"title":"Fe-S簇、血红素和谷胱甘肽络合金属通过膜转运体的细胞运输中底物选择的结构和序列基础。","authors":"J A Cowan","doi":"10.1016/j.jinorgbio.2025.113076","DOIUrl":null,"url":null,"abstract":"<p><p>Cellular mobilization of heme and iron‑sulfur cluster cofactors has been a topic of interest for over a decade. Recognition of glutathione-complexed clusters as viable mediators of intracellular trafficking of [2Fe-2S] cofactors and other metallosubstrates for transmembrane localization has been demonstrated both biochemically and by structural studies, and is supported by genetic analysis. Sequence and structural correlations of both eukaryotic and prokaryotic ATP-binding cassette (ABC) membrane transporter families (ABCB7 and ABCB6) reveals connections that address possible roles for ABCB6 in Fe-S cluster cellular mobilization and further clarify its role in heme transport. This review expands on these themes by correlating structural and sequence relationships between Fe-S cluster and heme transporters, and broader roles in mediating drug resistance and elimination of toxic metals.</p>","PeriodicalId":364,"journal":{"name":"Journal of Inorganic Biochemistry","volume":"274 ","pages":"113076"},"PeriodicalIF":3.2000,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Structural and sequence basis for substrate selection in the cellular trafficking of Fe-S clusters, hemes and glutathione-complexed metals through membrane transporters.\",\"authors\":\"J A Cowan\",\"doi\":\"10.1016/j.jinorgbio.2025.113076\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Cellular mobilization of heme and iron‑sulfur cluster cofactors has been a topic of interest for over a decade. Recognition of glutathione-complexed clusters as viable mediators of intracellular trafficking of [2Fe-2S] cofactors and other metallosubstrates for transmembrane localization has been demonstrated both biochemically and by structural studies, and is supported by genetic analysis. Sequence and structural correlations of both eukaryotic and prokaryotic ATP-binding cassette (ABC) membrane transporter families (ABCB7 and ABCB6) reveals connections that address possible roles for ABCB6 in Fe-S cluster cellular mobilization and further clarify its role in heme transport. This review expands on these themes by correlating structural and sequence relationships between Fe-S cluster and heme transporters, and broader roles in mediating drug resistance and elimination of toxic metals.</p>\",\"PeriodicalId\":364,\"journal\":{\"name\":\"Journal of Inorganic Biochemistry\",\"volume\":\"274 \",\"pages\":\"113076\"},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2025-09-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Inorganic Biochemistry\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1016/j.jinorgbio.2025.113076\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Inorganic Biochemistry","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1016/j.jinorgbio.2025.113076","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Structural and sequence basis for substrate selection in the cellular trafficking of Fe-S clusters, hemes and glutathione-complexed metals through membrane transporters.
Cellular mobilization of heme and iron‑sulfur cluster cofactors has been a topic of interest for over a decade. Recognition of glutathione-complexed clusters as viable mediators of intracellular trafficking of [2Fe-2S] cofactors and other metallosubstrates for transmembrane localization has been demonstrated both biochemically and by structural studies, and is supported by genetic analysis. Sequence and structural correlations of both eukaryotic and prokaryotic ATP-binding cassette (ABC) membrane transporter families (ABCB7 and ABCB6) reveals connections that address possible roles for ABCB6 in Fe-S cluster cellular mobilization and further clarify its role in heme transport. This review expands on these themes by correlating structural and sequence relationships between Fe-S cluster and heme transporters, and broader roles in mediating drug resistance and elimination of toxic metals.
期刊介绍：
The Journal of Inorganic Biochemistry is an established international forum for research in all aspects of Biological Inorganic Chemistry. Original papers of a high scientific level are published in the form of Articles (full length papers), Short Communications, Focused Reviews and Bioinorganic Methods. Topics include: the chemistry, structure and function of metalloenzymes; the interaction of inorganic ions and molecules with proteins and nucleic acids; the synthesis and properties of coordination complexes of biological interest including both structural and functional model systems; the function of metal- containing systems in the regulation of gene expression; the role of metals in medicine; the application of spectroscopic methods to determine the structure of metallobiomolecules; the preparation and characterization of metal-based biomaterials; and related systems. The emphasis of the Journal is on the structure and mechanism of action of metallobiomolecules.
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