选择性客体结合中易于分离的萨伦基隐烷外消旋和中位异构体。

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-10-09 DOI:10.1021/acs.orglett.5c03532

Zongjiang Yu, , , Shingo Sugimoto, , , Yoko Sakata, , and , Shigehisa Akine*,

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引用次数: 0

摘要

采用动态共价亚胺化学方法合成了一种可分离的中消旋异构体。单晶x射线分析证实了外消旋形式的结构。同分异构体在溶液中表现出缓慢的相互转化，使其性质的单独研究成为可能。外消旋异构体结合季铵客体具有显著的尺寸选择性，突出了亚胺基隐烷作为分子识别功能宿主的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Easily Separable Racemic and Meso Isomers of a Salen-Based Cryptophane for Selective Guest Binding

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Easily Separable Racemic and Meso Isomers of a Salen-Based Cryptophane for Selective Guest Binding

A salen-based cryptophane cage was synthesized via dynamic covalent imine chemistry, affording separable meso and racemic isomers. Single-crystal X-ray analysis confirmed the structure of the racemic form. The isomers exhibited slow interconversion in solution, enabling an individual study of their properties. The racemic isomer bound quaternary ammonium guests with notable size selectivity, highlighting the potential of imine-based cryptophanes as functional hosts for molecular recognition.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.