Nanda Deepa Thimmappa, Ayman Gaballah, Talissa Altes, Deepthi Rao, Andrew W Wheeler, Norbert Richardson, Joanne Cassani, Jacqueline Bailey, Yassin Labyed
{"title":"用超声提取的脂肪分数量化减肥手术后脂肪变性肝病的变化。","authors":"Nanda Deepa Thimmappa, Ayman Gaballah, Talissa Altes, Deepthi Rao, Andrew W Wheeler, Norbert Richardson, Joanne Cassani, Jacqueline Bailey, Yassin Labyed","doi":"10.1093/radadv/umaf018","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>A noninvasive, readily accessible, and quantitative methods are needed to evaluate changes in hepatic fat over time in patients undergoing bariatric surgery.</p><p><strong>Purpose: </strong>To measure the change in ultrasound-derived fat fraction (UDFF) in severely obese adults before and after bariatric surgery.</p><p><strong>Materials and methods: </strong>Participants undergoing bariatric surgery were prospectively enrolled at a single center and evaluated at 3 time points: pre-surgery (before a 2-week pre-operative liquid diet), day of surgery (immediately following the liquid diet), and 6 months post-surgery. Measurements included UDFF (Siemens Healthineers ACUSON SEQUOIA), skin-to-liver capsule thickness, serum metabolic tests, liver function tests, and anthropometric data. Changes in these variables were analyzed using 2-sided paired <i>t</i>-tests. Pearson correlation analysis was used to evaluate associations between changes in UDFF and changes in skin-to-capsule thickness, waist circumference, and BMI.</p><p><strong>Results: </strong>Seventeen participants (mean age 47.41 ± 11.11 years, 15 women) completed the study. UDFF (mean ± SD) decreased significantly from 20.4 ± 8.41% pre-surgery to 11.08 ± 6.33% at 6 months post-surgery (<i>P</i> < .001). Skin-to-liver capsule thickness decreased from 4.06 ± 0.66 cm to 2.88 ± 0.55 cm (<i>P</i> < .001). BMI decreased from 46.27 ± 6.65 kg/m<sup>2</sup> to 35.5 ± 6.64 kg/m<sup>2</sup> (<i>P</i> < .001), and waist circumference decreased from 130.29 ± 13.49 cm to 111.98 ± 16.03 cm (<i>P</i> < .001). No significant changes were observed in UDFF, skin-to-liver capsule thickness, or waist circumference after the liquid diet phase. Strong positive correlation between UDFF and BMI reduction was observed (r = 0.75, <i>P</i> < .001).</p><p><strong>Conclusions: </strong>Bariatric surgery results in significant reductions in hepatic steatosis, as measured by UDFF, and reductions in skin-to-liver capsule thickness, BMI, and waist circumference at 6 months post-surgery. These findings suggest that UDFF could meet the clinical need for noninvasive monitoring of hepatic steatosis following bariatric surgery.</p>","PeriodicalId":519940,"journal":{"name":"Radiology advances","volume":"2 3","pages":"umaf018"},"PeriodicalIF":0.0000,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12429188/pdf/","citationCount":"0","resultStr":"{\"title\":\"Quantifying changes in steatotic liver disease after bariatric surgery using ultrasound-derived fat fraction.\",\"authors\":\"Nanda Deepa Thimmappa, Ayman Gaballah, Talissa Altes, Deepthi Rao, Andrew W Wheeler, Norbert Richardson, Joanne Cassani, Jacqueline Bailey, Yassin Labyed\",\"doi\":\"10.1093/radadv/umaf018\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>A noninvasive, readily accessible, and quantitative methods are needed to evaluate changes in hepatic fat over time in patients undergoing bariatric surgery.</p><p><strong>Purpose: </strong>To measure the change in ultrasound-derived fat fraction (UDFF) in severely obese adults before and after bariatric surgery.</p><p><strong>Materials and methods: </strong>Participants undergoing bariatric surgery were prospectively enrolled at a single center and evaluated at 3 time points: pre-surgery (before a 2-week pre-operative liquid diet), day of surgery (immediately following the liquid diet), and 6 months post-surgery. Measurements included UDFF (Siemens Healthineers ACUSON SEQUOIA), skin-to-liver capsule thickness, serum metabolic tests, liver function tests, and anthropometric data. Changes in these variables were analyzed using 2-sided paired <i>t</i>-tests. Pearson correlation analysis was used to evaluate associations between changes in UDFF and changes in skin-to-capsule thickness, waist circumference, and BMI.</p><p><strong>Results: </strong>Seventeen participants (mean age 47.41 ± 11.11 years, 15 women) completed the study. UDFF (mean ± SD) decreased significantly from 20.4 ± 8.41% pre-surgery to 11.08 ± 6.33% at 6 months post-surgery (<i>P</i> < .001). Skin-to-liver capsule thickness decreased from 4.06 ± 0.66 cm to 2.88 ± 0.55 cm (<i>P</i> < .001). BMI decreased from 46.27 ± 6.65 kg/m<sup>2</sup> to 35.5 ± 6.64 kg/m<sup>2</sup> (<i>P</i> < .001), and waist circumference decreased from 130.29 ± 13.49 cm to 111.98 ± 16.03 cm (<i>P</i> < .001). No significant changes were observed in UDFF, skin-to-liver capsule thickness, or waist circumference after the liquid diet phase. Strong positive correlation between UDFF and BMI reduction was observed (r = 0.75, <i>P</i> < .001).</p><p><strong>Conclusions: </strong>Bariatric surgery results in significant reductions in hepatic steatosis, as measured by UDFF, and reductions in skin-to-liver capsule thickness, BMI, and waist circumference at 6 months post-surgery. These findings suggest that UDFF could meet the clinical need for noninvasive monitoring of hepatic steatosis following bariatric surgery.</p>\",\"PeriodicalId\":519940,\"journal\":{\"name\":\"Radiology advances\",\"volume\":\"2 3\",\"pages\":\"umaf018\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-04-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12429188/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Radiology advances\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1093/radadv/umaf018\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/5/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Radiology advances","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/radadv/umaf018","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/5/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
背景:需要一种无创的、容易获得的、定量的方法来评估接受减肥手术患者肝脂肪随时间的变化。目的:测量严重肥胖成人减肥手术前后超声脂肪含量(UDFF)的变化。材料和方法:接受减肥手术的参与者被前瞻性地纳入单一中心,并在3个时间点进行评估:术前(术前2周流食之前),手术当天(紧接着流食之后)和术后6个月。测量包括UDFF (Siemens Healthineers ACUSON SEQUOIA)、皮肤-肝囊厚度、血清代谢测试、肝功能测试和人体测量数据。使用双侧配对t检验分析这些变量的变化。使用Pearson相关分析来评估UDFF变化与皮肤-包膜厚度、腰围和BMI变化之间的关联。结果:17名参与者(平均年龄47.41±11.11岁,女性15名)完成了研究。UDFF (mean±SD)从术前的20.4±8.41%降至术后6个月的11.08±6.33% (P P 2降至35.5±6.64 kg/m2 (P P P P))。结论:减肥手术显著降低了肝脏脂肪变性(UDFF),并降低了术后6个月皮肤-肝包膜厚度、BMI和腰围。这些结果表明,UDFF可以满足临床对减肥手术后肝脂肪变性无创监测的需要。
Quantifying changes in steatotic liver disease after bariatric surgery using ultrasound-derived fat fraction.
Background: A noninvasive, readily accessible, and quantitative methods are needed to evaluate changes in hepatic fat over time in patients undergoing bariatric surgery.
Purpose: To measure the change in ultrasound-derived fat fraction (UDFF) in severely obese adults before and after bariatric surgery.
Materials and methods: Participants undergoing bariatric surgery were prospectively enrolled at a single center and evaluated at 3 time points: pre-surgery (before a 2-week pre-operative liquid diet), day of surgery (immediately following the liquid diet), and 6 months post-surgery. Measurements included UDFF (Siemens Healthineers ACUSON SEQUOIA), skin-to-liver capsule thickness, serum metabolic tests, liver function tests, and anthropometric data. Changes in these variables were analyzed using 2-sided paired t-tests. Pearson correlation analysis was used to evaluate associations between changes in UDFF and changes in skin-to-capsule thickness, waist circumference, and BMI.
Results: Seventeen participants (mean age 47.41 ± 11.11 years, 15 women) completed the study. UDFF (mean ± SD) decreased significantly from 20.4 ± 8.41% pre-surgery to 11.08 ± 6.33% at 6 months post-surgery (P < .001). Skin-to-liver capsule thickness decreased from 4.06 ± 0.66 cm to 2.88 ± 0.55 cm (P < .001). BMI decreased from 46.27 ± 6.65 kg/m2 to 35.5 ± 6.64 kg/m2 (P < .001), and waist circumference decreased from 130.29 ± 13.49 cm to 111.98 ± 16.03 cm (P < .001). No significant changes were observed in UDFF, skin-to-liver capsule thickness, or waist circumference after the liquid diet phase. Strong positive correlation between UDFF and BMI reduction was observed (r = 0.75, P < .001).
Conclusions: Bariatric surgery results in significant reductions in hepatic steatosis, as measured by UDFF, and reductions in skin-to-liver capsule thickness, BMI, and waist circumference at 6 months post-surgery. These findings suggest that UDFF could meet the clinical need for noninvasive monitoring of hepatic steatosis following bariatric surgery.