{"title":"(10) - 4-Chloro-phen-yl 4 - [(4-fluoro-phen-yl)氨基]5-phenyl-5, 8, 9, 10-tetra-hydro-pyrimido(4、5 b) quin-olin-6——(7 h)。","authors":"Adesola A Adeleke, Sizwe J Zamisa, Bernard Omondi","doi":"10.1107/S2414314625007758","DOIUrl":null,"url":null,"abstract":"<p><p>The title compound, C<sub>29</sub>H<sub>22</sub>ClFN<sub>4</sub>O, crystallizes with one mol-ecule in the asymmetric unit. The pyrimidinyl and anilinyl moieties subtend a dihedral angle = 36.65 (5)°, while the di-hydro-pyridine and phenyl rings are approximately orthogonal [dihedral angles = 81.65 (7) and 89.95 (7)°]. The crystal packing reveals alternating C-H⋯π and C-F⋯π inter-actions forming corrugated two-dimensional sheets along the <i>ac</i> plane, which are further linked into a three-dimensional network through N-H⋯O and C-H⋯O hydrogen bonds and Cl⋯Cl inter-actions.</p>","PeriodicalId":94324,"journal":{"name":"IUCrData","volume":"10 Pt 9","pages":"x250775"},"PeriodicalIF":0.0000,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12498024/pdf/","citationCount":"0","resultStr":"{\"title\":\"10-(4-Chloro-phen-yl)-4-[(4-fluoro-phen-yl)amino]-5-phenyl-5,8,9,10-tetra-hydro-pyrimido[4,5-<i>b</i>]quin-olin-6(7<i>H</i>)-one.\",\"authors\":\"Adesola A Adeleke, Sizwe J Zamisa, Bernard Omondi\",\"doi\":\"10.1107/S2414314625007758\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The title compound, C<sub>29</sub>H<sub>22</sub>ClFN<sub>4</sub>O, crystallizes with one mol-ecule in the asymmetric unit. The pyrimidinyl and anilinyl moieties subtend a dihedral angle = 36.65 (5)°, while the di-hydro-pyridine and phenyl rings are approximately orthogonal [dihedral angles = 81.65 (7) and 89.95 (7)°]. The crystal packing reveals alternating C-H⋯π and C-F⋯π inter-actions forming corrugated two-dimensional sheets along the <i>ac</i> plane, which are further linked into a three-dimensional network through N-H⋯O and C-H⋯O hydrogen bonds and Cl⋯Cl inter-actions.</p>\",\"PeriodicalId\":94324,\"journal\":{\"name\":\"IUCrData\",\"volume\":\"10 Pt 9\",\"pages\":\"x250775\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-09-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12498024/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"IUCrData\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1107/S2414314625007758\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/9/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"IUCrData","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1107/S2414314625007758","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/9/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
The title compound, C29H22ClFN4O, crystallizes with one mol-ecule in the asymmetric unit. The pyrimidinyl and anilinyl moieties subtend a dihedral angle = 36.65 (5)°, while the di-hydro-pyridine and phenyl rings are approximately orthogonal [dihedral angles = 81.65 (7) and 89.95 (7)°]. The crystal packing reveals alternating C-H⋯π and C-F⋯π inter-actions forming corrugated two-dimensional sheets along the ac plane, which are further linked into a three-dimensional network through N-H⋯O and C-H⋯O hydrogen bonds and Cl⋯Cl inter-actions.
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