{"title":"基于依赖滤波的可加性共享脆弱性模型的鲁棒估计。","authors":"Xin Chen, Jieli Ding, Liuquan Sun","doi":"10.1002/sim.70286","DOIUrl":null,"url":null,"abstract":"<p><p>Recurrent event data with dependent censoring frequently arise in medical follow-up studies. In analyzing such data, one main challenge is addressing the complex dependencies among the recurrent events, failure events, and censoring events. In this paper, we focus on additive shared-frailty models for recurrent event processes and failure times, and propose a robust estimation procedure that accommodates censoring times dependent on both recurrent and failure events, even after conditioning on observed covariates. Notably, our method does not require specifying the exact dependence structure between censoring and recurrent/failure times, nor does it assume a particular frailty distribution. We show that the resulting estimates are consistent and asymptotically normal. We further assess the method's finite-sample performance through simulation studies, and illustrate its practical utility with a hospitalization dataset.</p>","PeriodicalId":21879,"journal":{"name":"Statistics in Medicine","volume":"44 23-24","pages":"e70286"},"PeriodicalIF":1.8000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Robust Estimation of Additive Shared-Frailty Models for Recurrent Event Data With Dependent Censoring.\",\"authors\":\"Xin Chen, Jieli Ding, Liuquan Sun\",\"doi\":\"10.1002/sim.70286\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Recurrent event data with dependent censoring frequently arise in medical follow-up studies. In analyzing such data, one main challenge is addressing the complex dependencies among the recurrent events, failure events, and censoring events. In this paper, we focus on additive shared-frailty models for recurrent event processes and failure times, and propose a robust estimation procedure that accommodates censoring times dependent on both recurrent and failure events, even after conditioning on observed covariates. Notably, our method does not require specifying the exact dependence structure between censoring and recurrent/failure times, nor does it assume a particular frailty distribution. We show that the resulting estimates are consistent and asymptotically normal. We further assess the method's finite-sample performance through simulation studies, and illustrate its practical utility with a hospitalization dataset.</p>\",\"PeriodicalId\":21879,\"journal\":{\"name\":\"Statistics in Medicine\",\"volume\":\"44 23-24\",\"pages\":\"e70286\"},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2025-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Statistics in Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1002/sim.70286\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MATHEMATICAL & COMPUTATIONAL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Statistics in Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/sim.70286","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MATHEMATICAL & COMPUTATIONAL BIOLOGY","Score":null,"Total":0}
Robust Estimation of Additive Shared-Frailty Models for Recurrent Event Data With Dependent Censoring.
Recurrent event data with dependent censoring frequently arise in medical follow-up studies. In analyzing such data, one main challenge is addressing the complex dependencies among the recurrent events, failure events, and censoring events. In this paper, we focus on additive shared-frailty models for recurrent event processes and failure times, and propose a robust estimation procedure that accommodates censoring times dependent on both recurrent and failure events, even after conditioning on observed covariates. Notably, our method does not require specifying the exact dependence structure between censoring and recurrent/failure times, nor does it assume a particular frailty distribution. We show that the resulting estimates are consistent and asymptotically normal. We further assess the method's finite-sample performance through simulation studies, and illustrate its practical utility with a hospitalization dataset.
期刊介绍:
The journal aims to influence practice in medicine and its associated sciences through the publication of papers on statistical and other quantitative methods. Papers will explain new methods and demonstrate their application, preferably through a substantive, real, motivating example or a comprehensive evaluation based on an illustrative example. Alternatively, papers will report on case-studies where creative use or technical generalizations of established methodology is directed towards a substantive application. Reviews of, and tutorials on, general topics relevant to the application of statistics to medicine will also be published. The main criteria for publication are appropriateness of the statistical methods to a particular medical problem and clarity of exposition. Papers with primarily mathematical content will be excluded. The journal aims to enhance communication between statisticians, clinicians and medical researchers.