{"title":"男性起源的微嵌合与癌症风险：系统回顾和荟萃分析。","authors":"Jun Li, Tingting Shao, Junyan Kou, Liwei Ni","doi":"10.1186/s12885-025-14860-z","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Many women carry male cells of presumed fetal origin-so-called male-origin microchimerism (MOM) in their circulation and tissues. The association between MOM and cancer risk remains unclear. We aim to evaluate the effect of MOM on cancer risk among postpartum women.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted to identify relevant articles in databases of PubMed, EMBASE, and Web of Science. The data were extracted from eligible studies on the relationship between MOM and cancer risk. A random-effects model was applied to obtain the pooled relative risks (RRs) with 95% confidence intervals (95%CIs). Subgroup analysis, sensitivity analysis and publication bias and were also conducted.</p><p><strong>Results: </strong>Twelve studies involving 3078 participants were enrolled in the pooled analysis. Data on the risk of breast, colon, ovarian, endometrial, thyroid, and brain cancer were collected for quantitative analysis. Pooled analysis showed a significantly reduced rate of cancer (pooled RR = 0.51, 95%CI 0.32-0.82) among MOM-positive women.</p><p><strong>Conclusions: </strong>Individuals harboring MOM exhibits a significantly low risk of cancer.</p>","PeriodicalId":9131,"journal":{"name":"BMC Cancer","volume":"25 1","pages":"1528"},"PeriodicalIF":3.4000,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Male-origin microchimerism and risk of cancer: a systematic review and meta‑analysis.\",\"authors\":\"Jun Li, Tingting Shao, Junyan Kou, Liwei Ni\",\"doi\":\"10.1186/s12885-025-14860-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Many women carry male cells of presumed fetal origin-so-called male-origin microchimerism (MOM) in their circulation and tissues. The association between MOM and cancer risk remains unclear. We aim to evaluate the effect of MOM on cancer risk among postpartum women.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted to identify relevant articles in databases of PubMed, EMBASE, and Web of Science. The data were extracted from eligible studies on the relationship between MOM and cancer risk. A random-effects model was applied to obtain the pooled relative risks (RRs) with 95% confidence intervals (95%CIs). Subgroup analysis, sensitivity analysis and publication bias and were also conducted.</p><p><strong>Results: </strong>Twelve studies involving 3078 participants were enrolled in the pooled analysis. Data on the risk of breast, colon, ovarian, endometrial, thyroid, and brain cancer were collected for quantitative analysis. Pooled analysis showed a significantly reduced rate of cancer (pooled RR = 0.51, 95%CI 0.32-0.82) among MOM-positive women.</p><p><strong>Conclusions: </strong>Individuals harboring MOM exhibits a significantly low risk of cancer.</p>\",\"PeriodicalId\":9131,\"journal\":{\"name\":\"BMC Cancer\",\"volume\":\"25 1\",\"pages\":\"1528\"},\"PeriodicalIF\":3.4000,\"publicationDate\":\"2025-10-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"BMC Cancer\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1186/s12885-025-14860-z\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMC Cancer","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12885-025-14860-z","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
背景：许多女性在她们的循环和组织中携带假定是胎儿起源的男性细胞，即所谓的男性起源微嵌合（MOM）。MOM和癌症风险之间的关系尚不清楚。我们的目的是评估MOM对产后妇女癌症风险的影响。方法：在PubMed、EMBASE和Web of Science数据库中检索相关文献。这些数据是从MOM和癌症风险之间关系的合格研究中提取的。采用随机效应模型获得具有95%置信区间（95% ci）的合并相对风险（rr）。并进行亚组分析、敏感性分析和发表偏倚分析。结果：12项研究共纳入3078名受试者。收集乳腺癌、结肠癌、卵巢癌、子宫内膜癌、甲状腺癌和脑癌的风险数据进行定量分析。综合分析显示，孕妈妈阳性妇女的癌症发病率显著降低（综合RR = 0.51, 95%CI 0.32-0.82）。结论：携带MOM的个体患癌症的风险明显较低。
Male-origin microchimerism and risk of cancer: a systematic review and meta‑analysis.
Background: Many women carry male cells of presumed fetal origin-so-called male-origin microchimerism (MOM) in their circulation and tissues. The association between MOM and cancer risk remains unclear. We aim to evaluate the effect of MOM on cancer risk among postpartum women.
Methods: A comprehensive literature search was conducted to identify relevant articles in databases of PubMed, EMBASE, and Web of Science. The data were extracted from eligible studies on the relationship between MOM and cancer risk. A random-effects model was applied to obtain the pooled relative risks (RRs) with 95% confidence intervals (95%CIs). Subgroup analysis, sensitivity analysis and publication bias and were also conducted.
Results: Twelve studies involving 3078 participants were enrolled in the pooled analysis. Data on the risk of breast, colon, ovarian, endometrial, thyroid, and brain cancer were collected for quantitative analysis. Pooled analysis showed a significantly reduced rate of cancer (pooled RR = 0.51, 95%CI 0.32-0.82) among MOM-positive women.
Conclusions: Individuals harboring MOM exhibits a significantly low risk of cancer.
期刊介绍：
BMC Cancer is an open access, peer-reviewed journal that considers articles on all aspects of cancer research, including the pathophysiology, prevention, diagnosis and treatment of cancers. The journal welcomes submissions concerning molecular and cellular biology, genetics, epidemiology, and clinical trials.
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