以蓖麻油和二氯硫酸及癸二酸为原料高效合成光学纯大环聚内酯

IF 0.9 4区化学 Q4 CHEMISTRY, ORGANIC

Russian Journal of Organic Chemistry Pub Date : 2025-10-08 DOI:10.1134/S1070428025601682

M. P. Yakovleva, I. S. Nazarov, K. M. Saitov, G. Y. Ishmuratov, A. G. Tolstikov

{"title":"以蓖麻油和二氯硫酸及癸二酸为原料高效合成光学纯大环聚内酯","authors":"M. P. Yakovleva, I. S. Nazarov, K. M. Saitov, G. Y. Ishmuratov, A. G. Tolstikov","doi":"10.1134/S1070428025601682","DOIUrl":null,"url":null,"abstract":"An effective synthesis of optically pure macrocyclic polylactones is developed, involving the [1+1] condensation of a natural triol (castor oil) with thionyl chloride in carbon tetrachloride in the presence of DMF as a base and (N,N-dimethylamino)pyridine as a catalyst and followed by the [1+1] condensation of the resulting macrocyclic alcohol with sebacoyl chloride under similar conditions.","PeriodicalId":766,"journal":{"name":"Russian Journal of Organic Chemistry","volume":"61 8","pages":"1422 - 1426"},"PeriodicalIF":0.9000,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Efficient Synthesis of Optically Pure Macrocyclic Polylactones from Castor Oil and Sulfurous and Sebacic Acid Dichlorides\",\"authors\":\"M. P. Yakovleva, I. S. Nazarov, K. M. Saitov, G. Y. Ishmuratov, A. G. Tolstikov\",\"doi\":\"10.1134/S1070428025601682\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"An effective synthesis of optically pure macrocyclic polylactones is developed, involving the [1+1] condensation of a natural triol (castor oil) with thionyl chloride in carbon tetrachloride in the presence of DMF as a base and (N,N-dimethylamino)pyridine as a catalyst and followed by the [1+1] condensation of the resulting macrocyclic alcohol with sebacoyl chloride under similar conditions.\",\"PeriodicalId\":766,\"journal\":{\"name\":\"Russian Journal of Organic Chemistry\",\"volume\":\"61 8\",\"pages\":\"1422 - 1426\"},\"PeriodicalIF\":0.9000,\"publicationDate\":\"2025-10-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Russian Journal of Organic Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1134/S1070428025601682\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Journal of Organic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1134/S1070428025601682","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}

引用次数: 0

摘要

研究了一种光学纯大环聚内酯的有效合成方法，包括在四氯化碳中以DMF为碱，以（N，N-二甲胺）吡啶为催化剂，将天然三醇（蓖麻油）与亚硫酰氯进行[1+1]缩合，然后在类似条件下将所得的大环醇与癸二酰氯进行[1+1]缩合。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Efficient Synthesis of Optically Pure Macrocyclic Polylactones from Castor Oil and Sulfurous and Sebacic Acid Dichlorides

查看原文本刊更多论文

Efficient Synthesis of Optically Pure Macrocyclic Polylactones from Castor Oil and Sulfurous and Sebacic Acid Dichlorides

An effective synthesis of optically pure macrocyclic polylactones is developed, involving the [1+1] condensation of a natural triol (castor oil) with thionyl chloride in carbon tetrachloride in the presence of DMF as a base and (N,N-dimethylamino)pyridine as a catalyst and followed by the [1+1] condensation of the resulting macrocyclic alcohol with sebacoyl chloride under similar conditions.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Russian Journal of Organic Chemistry 化学-有机化学

CiteScore

1.40

自引率

25.00%

发文量

139

审稿时长

3-6 weeks

期刊介绍： Russian Journal of Organic Chemistry is an international peer reviewed journal that covers all aspects of modern organic chemistry including organic synthesis, theoretical organic chemistry, structure and mechanism, and the application of organometallic compounds in organic synthesis.