6,7-二甲氧基-1-（乙氧羰基）二氢异喹啉衍生物的合成

IF 0.9 4区化学 Q4 CHEMISTRY, ORGANIC

Russian Journal of Organic Chemistry Pub Date : 2025-10-08 DOI:10.1134/S1070428025601797

A. A. Aghekyan, H. A. Panosyan, A. S. Avagyan

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引用次数: 0

摘要

4-螺体融合的6,7-二甲氧基二氢异喹啉-1-羧酸的乙酯被还原为相应的1-（羟甲基）四氢异喹啉。后者与福尔马林环化形成恶唑异喹啉，然后经氢溴酸和浓盐酸处理再循环成四氢吡喃异喹啉。以螺融合的1-（羟甲基）异喹啉-6,7-二醇与二溴乙烷反应得到相应的二氧基异喹啉。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synthesis of Novel Fused Systems Derived from 4-Spiro-Fused 6,7-Dimethoxy-1-(ethoxycarbonyl)dihydroisoquinolines

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Synthesis of Novel Fused Systems Derived from 4-Spiro-Fused 6,7-Dimethoxy-1-(ethoxycarbonyl)dihydroisoquinolines

Ethyl esters of 4-spiro-fused 6,7-dimethoxydihydroisoquinoline-1-carboxylatic acids were reduced to the corresponding 1-(hydroxymethyl)tetrahydroisoquinolines. The latter were cyclized with Formalin to form oxazoloisoquinolines, which were then recyclized into tetrahydropyranoisoquinolines by treatment with hydrobromic and concentrated hydrochloric acids. Spiro-fused 1-(hydroxymethyl)isoquinoline-6,7-diols were reacted with dibromoethane to obtain the corresponding dioxinoisoquinolines.

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来源期刊

Russian Journal of Organic Chemistry 化学-有机化学

CiteScore

1.40

自引率

25.00%

发文量

139

审稿时长

3-6 weeks

期刊介绍： Russian Journal of Organic Chemistry is an international peer reviewed journal that covers all aspects of modern organic chemistry including organic synthesis, theoretical organic chemistry, structure and mechanism, and the application of organometallic compounds in organic synthesis.