免疫代谢：肿瘤代谢的串扰及其对肿瘤免疫治疗的意义

IF 33.9 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Cancer Pub Date : 2025-10-08 DOI:10.1186/s12943-025-02460-1

Huiru Zhang, Jialiang Fan, Deyang Kong, Yu Sun, Qi Zhang, Renshen Xiang, Shuaibing Lu, Wenjing Yang, Lin Feng, Haizeng Zhang

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引用次数: 0

摘要

免疫代谢通过解码代谢途径和免疫反应之间复杂的相互作用网络，为癌症免疫治疗建立了一个开创性的范式。本文全面探讨了肿瘤微环境中免疫细胞的代谢重编程，分析了关键代谢途径、酶和代谢物在免疫调节中的作用，揭示了肿瘤与免疫细胞之间复杂的代谢相互作用。此外，我们讨论了代谢干预如何增强抗肿瘤免疫反应，并强调了免疫代谢检查点作为治疗靶点的潜力。免疫代谢的未来研究将集中于先进技术的应用，新的代谢生物标志物的发现，以及代谢组学驱动的个性化医学，以推进癌症的诊断、治疗和精确肿瘤学。

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Immunometabolism: crosstalk with tumor metabolism and implications for cancer immunotherapy

Immunometabolism has established a groundbreaking paradigm for cancer immunotherapy by decoding the intricate interaction networks between metabolic pathways and immune responses. This review comprehensively explores the metabolic reprogramming of immune cells in the tumor microenvironment, analyzes the roles of key metabolic pathways, enzymes, and metabolites in immune regulation, and unveils the intricate metabolic interactions between tumor and immune cells. Furthermore, we discuss how metabolic interventions can enhance antitumor immune responses and highlight the potential of immunometabolic checkpoints as therapeutic targets. Future research in immunometabolism will focus on the application of advanced technologies, the discovery of novel metabolic biomarkers, and metabolomics-driven personalized medicine to advance cancer diagnosis, treatment, and precision oncology.

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来源期刊

Molecular Cancer 医学-生化与分子生物学

CiteScore

54.90

自引率

2.70%

发文量

224

审稿时长

2 months

期刊介绍： Molecular Cancer is a platform that encourages the exchange of ideas and discoveries in the field of cancer research, particularly focusing on the molecular aspects. Our goal is to facilitate discussions and provide insights into various areas of cancer and related biomedical science. We welcome articles from basic, translational, and clinical research that contribute to the advancement of understanding, prevention, diagnosis, and treatment of cancer. The scope of topics covered in Molecular Cancer is diverse and inclusive. These include, but are not limited to, cell and tumor biology, angiogenesis, utilizing animal models, understanding metastasis, exploring cancer antigens and the immune response, investigating cellular signaling and molecular biology, examining epidemiology, genetic and molecular profiling of cancer, identifying molecular targets, studying cancer stem cells, exploring DNA damage and repair mechanisms, analyzing cell cycle regulation, investigating apoptosis, exploring molecular virology, and evaluating vaccine and antibody-based cancer therapies. Molecular Cancer serves as an important platform for sharing exciting discoveries in cancer-related research. It offers an unparalleled opportunity to communicate information to both specialists and the general public. The online presence of Molecular Cancer enables immediate publication of accepted articles and facilitates the presentation of large datasets and supplementary information. This ensures that new research is efficiently and rapidly disseminated to the scientific community.