{"title":"草甘膦对心脏线粒体的急性作用不影响生物能量学。","authors":"Antonia Cugliari, Cristina Algieri, Micaela Fabbri, Fabiana Trombetti, Giulia Rampazzo, Teresa Gazzotti, Giampiero Pagliuca, Salvatore Nesci","doi":"10.1080/00498254.2025.2568631","DOIUrl":null,"url":null,"abstract":"<p><p>Considering the important role of mitochondria in mammalian cells and the close correlation between mitochondrial dysfunction and various diseases, this study evaluated the potential toxicity of glyphosate on mitochondrial function in swine heart mitochondria. The results indicated that glyphosate did not have a significant effect on mitochondrial respiration, mitochondrial swelling, and F<sub>1</sub>F<sub>O</sub>-ATPase activity under the experimental conditions tested. These findings suggest that, in this model, glyphosate alone may not exert a direct cardiotoxic effect on mitochondrial bioenergetics. However, caution is warranted when extrapolating these results to human health, as differences in species, exposure levels, and experimental conditions may influence outcomes. Moreover, the toxicity observed in glyphosate-based herbicides could involve adjuvants or synergistic interactions between glyphosate and other formulation components, as proposed by other studies.</p>","PeriodicalId":23812,"journal":{"name":"Xenobiotica","volume":" ","pages":"1-10"},"PeriodicalIF":1.2000,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The acute effect of glyphosate on heart mitochondria does not impair the bioenergetics.\",\"authors\":\"Antonia Cugliari, Cristina Algieri, Micaela Fabbri, Fabiana Trombetti, Giulia Rampazzo, Teresa Gazzotti, Giampiero Pagliuca, Salvatore Nesci\",\"doi\":\"10.1080/00498254.2025.2568631\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Considering the important role of mitochondria in mammalian cells and the close correlation between mitochondrial dysfunction and various diseases, this study evaluated the potential toxicity of glyphosate on mitochondrial function in swine heart mitochondria. The results indicated that glyphosate did not have a significant effect on mitochondrial respiration, mitochondrial swelling, and F<sub>1</sub>F<sub>O</sub>-ATPase activity under the experimental conditions tested. These findings suggest that, in this model, glyphosate alone may not exert a direct cardiotoxic effect on mitochondrial bioenergetics. However, caution is warranted when extrapolating these results to human health, as differences in species, exposure levels, and experimental conditions may influence outcomes. Moreover, the toxicity observed in glyphosate-based herbicides could involve adjuvants or synergistic interactions between glyphosate and other formulation components, as proposed by other studies.</p>\",\"PeriodicalId\":23812,\"journal\":{\"name\":\"Xenobiotica\",\"volume\":\" \",\"pages\":\"1-10\"},\"PeriodicalIF\":1.2000,\"publicationDate\":\"2025-10-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Xenobiotica\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/00498254.2025.2568631\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Xenobiotica","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/00498254.2025.2568631","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
The acute effect of glyphosate on heart mitochondria does not impair the bioenergetics.
Considering the important role of mitochondria in mammalian cells and the close correlation between mitochondrial dysfunction and various diseases, this study evaluated the potential toxicity of glyphosate on mitochondrial function in swine heart mitochondria. The results indicated that glyphosate did not have a significant effect on mitochondrial respiration, mitochondrial swelling, and F1FO-ATPase activity under the experimental conditions tested. These findings suggest that, in this model, glyphosate alone may not exert a direct cardiotoxic effect on mitochondrial bioenergetics. However, caution is warranted when extrapolating these results to human health, as differences in species, exposure levels, and experimental conditions may influence outcomes. Moreover, the toxicity observed in glyphosate-based herbicides could involve adjuvants or synergistic interactions between glyphosate and other formulation components, as proposed by other studies.
期刊介绍：
Xenobiotica covers seven main areas, including:General Xenobiochemistry, including in vitro studies concerned with the metabolism, disposition and excretion of drugs, and other xenobiotics, as well as the structure, function and regulation of associated enzymesClinical Pharmacokinetics and Metabolism, covering the pharmacokinetics and absorption, distribution, metabolism and excretion of drugs and other xenobiotics in manAnimal Pharmacokinetics and Metabolism, covering the pharmacokinetics, and absorption, distribution, metabolism and excretion of drugs and other xenobiotics in animalsPharmacogenetics, defined as the identification and functional characterisation of polymorphic genes that encode xenobiotic metabolising enzymes and transporters that may result in altered enzymatic, cellular and clinical responses to xenobioticsMolecular Toxicology, concerning the mechanisms of toxicity and the study of toxicology of xenobiotics at the molecular levelXenobiotic Transporters, concerned with all aspects of the carrier proteins involved in the movement of xenobiotics into and out of cells, and their impact on pharmacokinetic behaviour in animals and manTopics in Xenobiochemistry, in the form of reviews and commentaries are primarily intended to be a critical analysis of the issue, wherein the author offers opinions on the relevance of data or of a particular experimental approach or methodology
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