Lijun Ma, Young A Choi, DengFeng Li, Moin A Saleem, Barry I Freedman
{"title":"血清AKR1A1水平预测非裔2型糖尿病患者eGFR下降率","authors":"Lijun Ma, Young A Choi, DengFeng Li, Moin A Saleem, Barry I Freedman","doi":"10.34067/KID.0000000966","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>African Americans have disproportionately high rates of diabetic kidney disease (DKD). Identification of biomarkers predicting early DKD progression is essential to prescribe protective treatments prior to the development of irreversible histologic lesions and markedly reduced kidney function.</p><p><strong>Methods: </strong>We tested whether AKR1A1 was a marker of early DKD progression via knock-out of AKR1A1 in a human kidney proximal tubule cell line, and by measuring serum AKR1A1 concentrations in African Americans with type 2 diabetes (T2D).</p><p><strong>Results: </strong>AKR1A1 knockout cells had reduced cell viability, and the effect was aggravated by administering high dose palmitate. In addition, higher serum AKR1A1 concentrations in African Americans with T2D and preserved kidney function predicted slower decline rate in estimated glomerular filtration rate over time.</p><p><strong>Conclusions: </strong>AKR1A1 appears to play a critical role in countering toxic effects of fatty acid metabolism and may prevent rapid decline of kidney function in African Americans with T2D.</p>","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":" ","pages":""},"PeriodicalIF":3.0000,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Serum AKR1A1 Levels Predict eGFR Decline Rate in African Americans with Type 2 Diabetes.\",\"authors\":\"Lijun Ma, Young A Choi, DengFeng Li, Moin A Saleem, Barry I Freedman\",\"doi\":\"10.34067/KID.0000000966\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>African Americans have disproportionately high rates of diabetic kidney disease (DKD). Identification of biomarkers predicting early DKD progression is essential to prescribe protective treatments prior to the development of irreversible histologic lesions and markedly reduced kidney function.</p><p><strong>Methods: </strong>We tested whether AKR1A1 was a marker of early DKD progression via knock-out of AKR1A1 in a human kidney proximal tubule cell line, and by measuring serum AKR1A1 concentrations in African Americans with type 2 diabetes (T2D).</p><p><strong>Results: </strong>AKR1A1 knockout cells had reduced cell viability, and the effect was aggravated by administering high dose palmitate. In addition, higher serum AKR1A1 concentrations in African Americans with T2D and preserved kidney function predicted slower decline rate in estimated glomerular filtration rate over time.</p><p><strong>Conclusions: </strong>AKR1A1 appears to play a critical role in countering toxic effects of fatty acid metabolism and may prevent rapid decline of kidney function in African Americans with T2D.</p>\",\"PeriodicalId\":17882,\"journal\":{\"name\":\"Kidney360\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2025-10-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Kidney360\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.34067/KID.0000000966\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"UROLOGY & NEPHROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Kidney360","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.34067/KID.0000000966","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
Serum AKR1A1 Levels Predict eGFR Decline Rate in African Americans with Type 2 Diabetes.
Background: African Americans have disproportionately high rates of diabetic kidney disease (DKD). Identification of biomarkers predicting early DKD progression is essential to prescribe protective treatments prior to the development of irreversible histologic lesions and markedly reduced kidney function.
Methods: We tested whether AKR1A1 was a marker of early DKD progression via knock-out of AKR1A1 in a human kidney proximal tubule cell line, and by measuring serum AKR1A1 concentrations in African Americans with type 2 diabetes (T2D).
Results: AKR1A1 knockout cells had reduced cell viability, and the effect was aggravated by administering high dose palmitate. In addition, higher serum AKR1A1 concentrations in African Americans with T2D and preserved kidney function predicted slower decline rate in estimated glomerular filtration rate over time.
Conclusions: AKR1A1 appears to play a critical role in countering toxic effects of fatty acid metabolism and may prevent rapid decline of kidney function in African Americans with T2D.
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