使用盒式放射性合成器自动制造碳-11放射性药物。

IF 0.9 4区医学 Q4 BIOCHEMICAL RESEARCH METHODS

Journal of labelled compounds & radiopharmaceuticals Pub Date : 2025-09-01 DOI:10.1002/jlcr.4166

Michael L Schulte, Adam J Rosenberg

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引用次数: 0

摘要

随着放射化学领域向放射性药物的快速发展和转化迈进，放射性合成的方法和制造也越来越精细。由于放射性药物在临床研究中的应用是放射化学研究的主要目标之一，因此符合cGMP法规是放射合成发展的关键因素。本综述主要集中在模块上的放射性合成自动化，特别侧重于反应堆和流动路径的一次性磁带的使用。本文综述了碳-11放射性药物盒式放射性合成的最新进展和现状。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Automated Manufacturing of Carbon-11 Radiopharmaceuticals Using Cassette-Based Radiosynthesizers.

As the field of radiochemistry moves toward the rapid development and translation of radiopharmaceuticals, the radiosynthetic methodology and manufacturing are becoming more and more refined. As the use of radiopharmaceuticals in clinical research is one of the primary goals of radiochemistry research, compliance with cGMP regulations is a key factor in radiosynthesis developments. This review is primarily focused on the automation of the radiosynthesis on modules, with a special focus on the use of disposable cassettes for the reactors and flow-paths. This review aims to cover the developments and current state-of-the-art for cassette-based radiosynthesis of carbon-11 radiopharmaceuticals.

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来源期刊

Journal of labelled compounds & radiopharmaceuticals 医学-分析化学

CiteScore

3.30

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： The Journal of Labelled Compounds and Radiopharmaceuticals publishes all aspects of research dealing with labeled compound preparation and applications of these compounds. This includes tracer methods used in medical, pharmacological, biological, biochemical and chemical research in vitro and in vivo. The Journal of Labelled Compounds and Radiopharmaceuticals devotes particular attention to biomedical research, diagnostic and therapeutic applications of radiopharmaceuticals, covering all stages of development from basic metabolic research and technological development to preclinical and clinical studies based on physically and chemically well characterized molecular structures, coordination compounds and nano-particles.