环状RNA在前列腺癌中的作用和功能。

IF 2.4 3区生物学 Q2 GENETICS & HEREDITY

Gene Pub Date : 2025-10-04 DOI:10.1016/j.gene.2025.149801

Xuan Shu , Jiaming Wang , Danni Chen , Yuxiao Li , Yuchen Shi , Hong Chen , Liping Xie , Jindan Luo

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引用次数: 0

摘要

环状RNA （circRNA）是一类非编码RNA，其共价闭合的环状结构具有很高的稳定性和抗降解性。近年来，环状rna已成为各种生物过程中的关键调节因子，通过调节基因转录、与miRNA的竞争性结合、与蛋白质的相互作用和编码肽等机制影响肿瘤的发生和进展，使其成为潜在的新型肿瘤生物标志物或治疗靶点。在世界许多国家和地区，前列腺癌正日益成为男性最常见的癌症。然而，前列腺癌恶性进展的具体分子机制仍未完全确定。本文就circRNA在前列腺癌中的调控作用及分子机制进行综述，重点从细胞周期、细胞增殖、凋亡、铁凋亡、迁移、侵袭、转移、耐药或放疗、免疫微环境等生物学功能方面进行综述。我们为circRNA在前列腺癌中的作用、功能和潜在临床应用提供了先进的见解。

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The roles and function of circular RNA in prostate cancer

Circular RNA (circRNA), a class of non-coding RNAs characterized by its covalently closed circular structure, exhibits high stability and resistance to degradation. Over recent years, circRNAs have emerged as key regulators in various biological processes, which influence tumorigenesis and progression through mechanisms such as regulating gene transcription, competitively binding to miRNA, interacting with proteins, and encoding peptides, making it a potential novel tumor biomarker or therapeutic target. Prostate cancer is increasingly becoming the most common cancer among men in many countries and regions worldwide. However, the specific molecular mechanism of malignant progression of prostate cancer is still not fully determined. In this review, we summarize the regulatory roles and molecular mechanisms of circRNA in prostate cancer, focusing on biological functions such as cell cycle, cell proliferation, apoptosis, ferroptosis, migration, invasion, metastasis, drug or radiotherapy resistance, and immune microenvironment. We provide advanced insights on the role, functions and potential clinical applications of circRNA in prostate cancer.

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来源期刊

Gene 生物-遗传学

CiteScore

6.10

自引率

2.90%

发文量

718

审稿时长

42 days

期刊介绍： Gene publishes papers that focus on the regulation, expression, function and evolution of genes in all biological contexts, including all prokaryotic and eukaryotic organisms, as well as viruses.