门缘苔藓细胞对尖锐波纹的分布阈下表征。

IF 6.4 1区 生物学 Q1 BIOLOGY
eLife Pub Date : 2025-10-07 DOI:10.7554/eLife.97270
Ayako Ouchi, Taro Toyoizumi, Nobuyoshi Matsumoto, Yuji Ikegaya
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引用次数: 0

摘要

在神经信息处理中,神经系统在神经回路层之间传递神经元活动,偶尔会穿过仅由稀疏神经元组成的小层。海马门苔藓细胞(hippocampus hilar moss cells, MCs)就是这样一个典型的瓶颈层。然而,如何在这些受约束的层中实现有效的信息编码仍然知之甚少。为了解决这个问题,我们专注于尖锐波波纹(swr) -起源于CA3区域的同步神经事件-并使用小鼠体内/体外膜片钳记录研究MC种群的功能多样性。通过结合机器学习算法,我们建立了一个基于MCs突触反应波形预测CA3 SWR波形的模型,表明SWR相关信息确实编码在MCs的阈下活动中。虽然单个MCs通常与特定的SWR集群相关,但也观察到一些MCs之间的部分重叠,表明CA3活性分布在整个MCs群体中。我们的研究结果表明,CA3 SWR活性在MC群体中以伪正交的方式表示,允许小MC层有效地压缩和传递海马信息。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Distributed subthreshold representation of sharp wave-ripples by hilar mossy cells.

Distributed subthreshold representation of sharp wave-ripples by hilar mossy cells.

Distributed subthreshold representation of sharp wave-ripples by hilar mossy cells.

Distributed subthreshold representation of sharp wave-ripples by hilar mossy cells.

In neural information processing, the nervous system transmits neuronal activity between layers of neural circuits, occasionally passing through small layers composed only of sparse neurons. Hippocampal hilar mossy cells (MCs) constitute such a typical bottleneck layer. However, how efficient information encoding is achieved within such constrained layers remains poorly understood. To address this, we focused on sharp wave-ripples (SWRs) - synchronous neural events originating in the CA3 region - and investigated functional diversity within MC populations using in vivo/in vitro patch-clamp recordings in mice. By combining machine learning algorithms, we developed a model to predict CA3 SWR waveforms based on the synaptic response waveforms of MCs, suggesting that SWR-related information is indeed encoded in their subthreshold activity. While individual MCs were generally associated with specific SWR clusters, partial overlap across some MCs was also observed, indicating that CA3 activity is distributed across the MC population. Our findings suggest that CA3 SWR activity is represented in a pseudo-orthogonal manner across MC populations, allowing the small MC layer to effectively compress and relay hippocampal information.

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来源期刊
eLife
eLife BIOLOGY-
CiteScore
12.90
自引率
3.90%
发文量
3122
审稿时长
17 weeks
期刊介绍: eLife is a distinguished, not-for-profit, peer-reviewed open access scientific journal that specializes in the fields of biomedical and life sciences. eLife is known for its selective publication process, which includes a variety of article types such as: Research Articles: Detailed reports of original research findings. Short Reports: Concise presentations of significant findings that do not warrant a full-length research article. Tools and Resources: Descriptions of new tools, technologies, or resources that facilitate scientific research. Research Advances: Brief reports on significant scientific advancements that have immediate implications for the field. Scientific Correspondence: Short communications that comment on or provide additional information related to published articles. Review Articles: Comprehensive overviews of a specific topic or field within the life sciences.
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