抗原特异性耐受性：自身免疫的临床和临床前方法。

IF 3.7 3区医学 Q2 IMMUNOLOGY

European Journal of Immunology Pub Date : 2025-10-06 DOI:10.1002/eji.70067

Priscilla P. M. Faas, Stephanie D. Scharmann, Novalia Pishesha

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引用次数: 0

摘要

自身免疫性疾病是由免疫耐受的破坏引起的。这会导致自我反应性免疫反应和慢性炎症。诱导抗原特异性耐受提供了一种有针对性的方法，可以在不抑制全局免疫的情况下恢复免疫平衡。我们讨论了目前寻求诱导耐受性的治疗方法。这些方法包括肽类、免疫球蛋白类、载体类和细胞类。我们回顾了临床试验和临床前研究，探讨了诱导持久（抗原特异性）耐受性的新策略，作为自身免疫性疾病的可能干预措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Antigen-Specific Tolerance: Clinical and Preclinical Approaches in Autoimmunity

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Antigen-Specific Tolerance: Clinical and Preclinical Approaches in Autoimmunity

Autoimmune diseases arise from a breakdown in immune tolerance. This leads to self-reactive immune responses and chronic inflammation. Induction of antigen-specific tolerance offers a targeted approach that restores immune balance without global immunosuppression. We discuss current approaches to therapies that seek to induce tolerance. These include peptide-, immunoglobulin-, carrier-, and cell-based approaches. We review clinical trials and preclinical studies that explore novel strategies for the induction of durable (antigen-specific) tolerance as possible interventions in autoimmune disease.

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来源期刊

European Journal of Immunology 医学-免疫学

CiteScore

8.30

自引率

3.70%

发文量

224

审稿时长

2 months

期刊介绍： The European Journal of Immunology (EJI) is an official journal of EFIS. Established in 1971, EJI continues to serve the needs of the global immunology community covering basic, translational and clinical research, ranging from adaptive and innate immunity through to vaccines and immunotherapy, cancer, autoimmunity, allergy and more. Mechanistic insights and thought-provoking immunological findings are of interest, as are studies using the latest omics technologies. We offer fast track review for competitive situations, including recently scooped papers, format free submission, transparent and fair peer review and more as detailed in our policies.