IgG-和iga相关自身抗体联合检测在胃癌早期诊断中的价值。

IF 1.9
Congcong Fu, Tao Wang, Xianzhu Zhou, Jianmin Fang, Yanlin Wang, Yuxin Wang, Xiaomao Yin, Wei Zhu, Hua Dong, Yiqi Du, Shuhong Luo, Ruo-Pan Huang
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引用次数: 0

摘要

肿瘤相关抗原(TAAs)的自身抗体由于其特异性和稳定性,是一种很有前途的非侵入性癌症生物标志物。胃癌(GC)的诊断通常需要侵入性手术,强调需要可靠的血液生物标志物。目的探讨血清IgG和IgA自身抗体单独或联合是否可作为胃癌的无创生物标志物。实验设计采用蛋白芯片技术分析265名健康对照者、296名胃癌患者和195名胃炎患者血清中的27种自身抗体。计算自身抗体水平和IgG/IgA比值。采用受试者工作特征(ROC)曲线评估诊断准确性。结果GC患者与对照组存在24种IgA和17种IgG自身抗体的差异表达。在鉴别胃癌和胃炎时,IgA的DEAs为20,IgG的DEAs为23。MIP1 β的IgG/IgA比值在萎缩性胃炎和胃癌之间的诊断效能最高,而MMP7在慢性胃炎和胃癌之间的诊断效能最高。与对照组相比,含有14种自身抗体的gbm模型胃癌的约登指数最高,而含有13种自身抗体的模型胃癌对所有胃炎的约登指数最好。结论特异性自身抗体可作为鉴别胃癌与对照组及胃炎的无创诊断工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Combination detection of IgG- and IgA-related autoantibodies for the early diagnosis of gastric cancer.

BackgroundAutoantibodies against tumor-associated antigens (TAAs) are promising noninvasive cancer biomarkers due to their specificity and stability. Gastric cancer (GC) diagnosis often requires invasive procedures, emphasizing the need for reliable blood-based biomarkers.ObjectiveThis study assessed whether serum IgG and IgA autoantibodies, individually or combined, could serve as noninvasive biomarkers for gastric cancer.Experimental designWe analyzed 27 autoantibodies in serum from 265 healthy controls, 296 GC patients, and 195 gastritis patients using protein microarray. Autoantibody levels and the IgG/IgA ratio were calculated. Diagnostic accuracy was evaluated using receiver operating characteristic (ROC) curves.ResultsWe identified 24 differentially expressed autoantibodies (DEAs) for IgA and 17 for IgG between GC patients and controls. In distinguishing GC from gastritis, 20 DEAs for IgA and 23 for IgG were significant. The IgG/IgA ratio of MIP1 beta had the highest diagnostic performance between atrophic gastritis and GC, while MMP7 was the most effective between chronic gastritis and GC. The gbm model with 14 autoantibodies had the highest Youden's index for GC versus controls, and a 13-autoantibody model performed best for GC versus all gastritis.ConclusionsSpecific panels of autoantibodies could serve as noninvasive diagnostic tools for distinguishing GC from controls and gastritis.

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